Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Receptors, LDL"”.
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Analysis of the Function of Megf7 During Development
Lrp4/Megf7, a member of the low-density lipoprotein receptor gene family, is a major regulator of tissue patterning during embryonic development. Prior to this work, the function Megf7 had largely been unknown. Eight distinct mutations in Megf7 were introduced into mice in order to facilitate a …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
… and that the secreted PCSK9 binds and degrades LDLRs in liver. To determine if PCSK9 catalytic activity was involved in the degradation of the LDLR, a mutant PCSK9 was engineered that is catalytically inactive. Studies with catalytically inactive PCSK9 demonstrated that the protein degraded …