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Showing 1 to 1 of 1 for “"Receptors, Erythropoietin"”.
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
Erythropoietin (Epo) is the primary cytokine that drives red blood cell production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these …