Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Receptors, Cytoplasmic and Nuclear"”.
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
The orphan nuclear hormone receptor, DAF-12, plays a central role in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… metabolism is an interwoven series of pathways and events acting in concert to control the nutritional and metabolic needs of the body. When alterations in lipid balance occur they can result in disease, thus an understanding of the pathophysiology, as well as the molecular mediators of these …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
The nuclear receptor DAF-12 plays a central role in controlling the larval development of C. elegans. Activation of DAF-12 by its ligands called dafachronic acids (DAs) commits the nematode to development into reproductive adult, which will otherwise arrest at a diapause stage called dauer. But the …
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Nuclear Export Signal Recognition by CRM1 Carrying the Oncogenic E571K Mutation and Structure-Based NES Prediction
Nuclear-cytoplasmic trafficking is an essential cellular process in eukaryotes that maintains and regulates the spatial distribution of key cellular processes in the nucleus and the cytoplasm. CRM1 is the major nuclear export mediator, which facilitates nuclear export of hundreds of protein and RNA …
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Nuclear Receptors in Lung Cancer
… a relatively well-known etiology (e.g. smoking) and has been widely researched, clinical tools and markers for early diagnosis, prognostic prediction, and therapeutic interventions remain limited. Here, for the first time, I propose a novel translational approach for providing diagnostic, …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
The nuclear receptor DAF-12, first identified in C. elegans, controls nematode species' entry into and exit from metabolically hypoactive resting states. In all of the parasitic species studied thus far, that resting state is the infectious third larval (iL3) stage, and activation of the receptor …
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Exploration of Nuclear Receptor Activity and siRNA-Derived Phenotypes as Therapeutics in Non-Small Cell Lung Cancer
Nuclear hormone receptors are master regulators of diverse cellular functions implicated in tumor pathogenesis and as oncogenic drivers of many human cancers. To better understand what role these important receptors might be playing in lung cancer, three interconnected studies were initiated to …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
… is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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DAF-12: A Novel Drug Target in Parasitic Nematodes
The nuclear receptor DAF-12, first identified in C. elegans, controls nematode species' entry into and exit from metabolically hypoactive resting states. In all of the parasitic species studied thus far, that resting state is the infectious third larval (iL3) stage, and activation of the receptor …
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Nuclear Export Receptor CRM1 Recognizes Nuclear Export Signals with Diverse Conformations
… facilitates export of hundreds of proteins and RNA molecules from eukaryotic cell nuclei. CRM1 recognizes its protein cargoes by their 8-15 residues-long nuclear export signals or NESs, which bind to a hydrophobic groove in CRM1. NESs are highly variable in sequence and structure. Their …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… We have tested the use of parallel in vitro and in vivo screens using a mini-library of shRNAs to identify previously unknown acquired vulnerabilities in lung cancer. Using a mini-library of 1062 lentiviral shRNAs targeting nuclear hormone receptors and their coregulators (120 genes total), …
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Identification of Oncogenic KRAS-Associated Vulnerabilities in Non-Small Cell Lung Cancer
… a prevalent miRNA-like behavior of siRNA and cell line-dependent phenotypic diversity within intra-lineage KRAS-driven cancer. In consideration of these, we performed a whole-genome synthetic-lethal siRNA screen, powered by 106 NSCLC lines and integrated with gene set enrichment analysis. …