Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Receptor-ligand interactions"”.
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Gonadotropin releasing hormone receptor ligand interactions
… regulator of reproductive function. It binds to receptors on the gonadotrope cells of the pituitary and stimulates release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Eleven different structural forms of GnRH have now been identified in various animal species. Chimaeric …
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Quantification of receptor-ligand interactions on bioengineered autocrine call system : a comparision of theory and experiments
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1997.
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Computational analysis of cell-cell communication in the tumor microenvironment
… therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can provide significant benefit for patients. However, our knowledge of this complex network of cell-cell interactions in a tumor microenvironment is still incomplete, …
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Antibody-Antigen assay design for combined optical tweezers and fluorescence
… promises to enable unbindinig force studies of receptor-ligand interactions, whose specificity play a crucial role in the function of many biological systems. This thesis focuses on the development of assay designs for the study of antibody-antigen binding interactions using combined optical …
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Biophysical regulation of cell motility by adhesion ligands and growth factors : effect of spatial presentation of the ligand
… replacements requires understanding of the interactions between the cell and its environment - the surface with which it interfaces and the fluid medium surrounding it. We are interested in designing a biologically inspired substrata which controls mammalian cell migration based on …
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Therapeutic applications of DNA origami-based programmable nanoparticles
… platforms only offer control over average ligand density. In this thesis, we demonstrate the therapeutic utility of DNA origami for cancer and infectious diseases. First, we demonstrate that modulating the nanoscale arrangement of an adjuvant enhances the efficacy of cancer vaccines. …
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Mechanisms of Gradient Tracking During Yeast Mating
… chemical gradients, despite tiny differences in receptor occupancy across the cell. Stochastic receptor-ligand interactions introduce considerable noise in instantaneous receptor occupancy, so it is thought that spatial information must be integrated over time to allow noise filtering. The …
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Kinetics of notch signaling during osteoclastogenesis
… Osteoclastogenesis is initiated in BMMs by receptor activator of nuclear factor kappa-B ligand (RANKL) in the presence of Macrophage Colony Stimulating Factor (M-CSF). This pathway consists of four membrane bound receptors and 5 membrane bound ligands including Jagged1 which is known to play …
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Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
… need for novel anti-parasitic drugs. Cys-loop ligand gated ion channels have been recognized as important invertebrate specific drug targets. However, specific targets must be identified and characterized prior to drug development. This thesis describes the identification and partial …
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Impacts of ocean acidification on fitness and chemical communication in a model marine invertebrate, Nereis succinea
… change in signal molecules and/or protein receptors, reducing receptor-ligand interactions. As the chemical sense is dominant in ocean environments, any reduction in its efficiency will likely have negative implications for the survival of marine organisms. This research highlights how near …
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated …
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Protein segregation and conformation in antigen-receptor triggering: a quantitative fluorescence microscopy study
Antigen receptors play a central role in determining whether an immune response is required. The remarkable diversity of their extracellular domains allows them to detect unfamiliar pathogens. In response, information is conveyed across the plasma membrane, resulting in the phosphorylation of …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a …
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Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
… host response. In addition, a unique set of receptors mediate uptake of host macromolecules and must comply with recognising ligands from a broad host range whilst also avoiding immune detection. Host transferrin (Tf) is acquired by trypanosomes through the expression of a transferrin …
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Tumor-induced macrophage and T cell dysfunction
… surface molecules, which suggests that specific receptor-ligand interactions modulate MΦ cell-cycle kinetics differently in the tumor-bearing host (TBH). Tumor growth changed MΦ responsiveness to MΦ colony-stimulating factor (M-CSF). M-CSF did not reverse decreases in autorecognition caused by …
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Multi-scale models of T cell activation
… of a G-protein RasGDP to RasGTP in the T cell receptor (TCR) membrane-proximal signaling network may enable such "short term memory". I developed a multiscale computational model that combines stochastic simulations of the TCR membrane-proximal signaling network with T cell migration. The …
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Interactions between integral membrane proteins and the cytoskeleton in red blood cells studied by measured molecular lateral diffusion
Integral membrane receptor proteins are involved in many aspects of biological function. These proteins are restricted to the lipid bilayer but can move laterally within it and interact with specific agents which control their functional activity. The agents, collectively termed ligands, are …
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Static and Microfluidic Live Imaging Studies of Plasmodium falciparum Invasion Phenotypes
… invasion is a complex process involving dynamic interactions between ligands in the merozoite coat and receptors on the red blood cell membrane. Therefore, filming the complete malaria invasion processes may shed the light on its mechanism. The rationale of this work is that learning how the …
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Exploring the molecular signatures of the ligand-receptor-Gi/o protein interactions of adenosine A1 and A3 receptors
Human adenosine A1 receptor (hA1R) and adenosine A3 receptors (hA3R) are two closely related class A Gi/o-coupled receptors. Both of them represented valuable therapeutic targets and various types of ligands have been developed for regulating their activities. hA1R has important implications in …
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New approaches to understanding the interactions between Plasmodium falciparum merozoites and human erythrocytes during invasion
… Invasion is a complex process involving multiple receptor-ligand interactions and multiple steps. It begins with attachment of the parasite to the erythrocyte, followed by reorientation to position the parasite to invade, then strong membrane wrapping occurs, and finally, a tight junction is …
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