Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Receptor-ligand interaction"”.
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The Design of Polyelectrolyte Multilayers Using Galactosylated Chitosan
… a surface protein, called the asialoglycoprotein receptor (ASGP-R), which interacts with galactose via a specific receptor-ligand interaction. Polyelectrolyte multilayers (PEMs) were prepared by the layer by layer method, which is based on electrostatic attractions between oppositely charged …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
<p>Glycosylation of immune receptors and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of …
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Computational and synthetic approaches in the design and development of chemical probes for estrogen receptor function
A member of the nuclear receptor superfamily, the estrogen receptor (ER) is a ligand-regulated transcription factor responsible for the regulation of hundreds of genes. Consequently, ERs are involved in numerous disease states, including cellular proliferation, post-menopausal symptoms, …
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Delivery of sting agonist using lipid nanoparticles and discovery of anti-TIGIT peptides for cancer therapy
… checkpoints, where cancer cells manipulate the interaction between a receptor on T cells and a ligand on cancer cells. This manipulation often involves the cancer cells overexpressing their specific ligands, leading to a phenomenon where T cells become exhausted and unable to effectively …
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Charakterisierung des Zytokins BAFF als wichtiger Regulator der B-Zellfunktion beim Haushuhn
… identify target cells for this cytokine, chBAFF receptor(s) expression was investigated in binding studies with Flag tagged chBAFF (Flag-chBAFF) and binding was analysed by flow cytometry. Receptor expression was clearly restricted to B-cells including mature B-cells from peripheral lymphoid …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… the biochemical mechanisms and molecular interactions underpinning Ebola Virus Disease represents a clearly unmet therapeutic need. Initially, the virus replicates to very high levels in macrophages and dendritic cells, both evading recognition and also actively suppressing the innate …
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Gezielte Modifikation sowie Analyse der Bindungseigenschaften des Histidin Bindeproteins aus Escherichia coli und des GCN4 Leucinzippers aus Saccharomyces cerevisiae
… ins Zytoplasma beteiligt und besitzt für seinen Liganden eine Affinität im nanomolaren Bereich. Durch Austausch eines Leucinrestes an Position 52 gegen ein Phenylalanin konnte die Affinität des HisJ für Histidin, Arginin und Lysin deutlich erhöht werden. Durch Bestimmung der Bindungskonstanten …