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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 25 for “"Receptor tyrosine kinase (RTK)"”.

  1. Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents

    Zhang, Xin2018

    … research progress in the areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and anti mitotic agents has been discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that …

    duquesne Repository record

  2. Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells

    Funk, Cory C.University of Illinois at Urbana-Champaign2015

    … gene. LRIG1 is a negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen receptor-alpha (ERalpha) and we identified the regions of the LRIG1 gene to which ER binds. LRIG1 regulation by estradiol helps to explain …

    uiuc Repository record

  3. New Methods for Characterizing the Complex Neural Circuitry of the Adult Drosophila Brain

    Zugates, Christopher T.University of Illinois at Urbana-Champaign2015

    … a non-autonomous requirement for the atypical receptor tyrosine kinase (RTK), Linotte/Derailed (Lio/Drl), in patterning MB axon lobe architecture. In the development of MB circuitry, Lio/Drl may act to counter Wnt5 signaling, which appears to be generally required for axon extension across the …

    uiuc Repository record

  4. The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth

    Lou, Jieqiong2017

    <p>Macrophage colony stimulating factor receptor (MCSFR a.k.a CSF-1R), is a receptor tyrosine kinase (RTK) that is essential for the growth of myeloid stem cells, monocytes and macrophages. Proper control of signaling through the MCSFR is critical for proper macrophage development and function. …

    sdstate Repository record

  5. Computational methodologies and resources for discovery of phosphorylation regulation and function in cellular networks

    Naegle, Kristen MMassachusetts Institute of Technology2010

    … proteins in the cell. For example, signaling in receptor tyrosine kinase (RTK) networks, such as those downstream of epidermal growth factor receptor (EGFR) and insulin receptor, is initiated by binding of cytokines or growth factors, and is generally propagated by phosphorylation of signaling …

    mit Repository record

  6. The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy

    Gaur, Sanchaika2015

    … understanding of how cross talk between tyrosine kinase receptors contributes to therapy resistance, and how this may be overcome by downregulating expression of these receptors. In PCa cell lines and xenograft models, I demonstrated that activation of IGF-1R receptor tyrosine kinase …

    uthsc Repository record

  7. Investigating the mechanisms and outcomes of Sprouty-2 S-acylation

    Locatelli, CarolinaUniversity of Strathclyde2021

    … Sprouty (SPRY) proteins are regulators of Receptor Tyrosine Kinase (RTK) signalling and play a major role in maintaining cellular homeostasis. Indeed, their deregulation is linked to tumorigenesis, developmental defects and neurological diseases.;The defining feature of SPRY proteins is a …

    strathclyde Repository record

  8. Dissecting mechanisms and consequences of oncogenic RTK fusion signaling

    Gonzalez Martinez, David , Alejandro2026

    Receptor tyrosine kinase (RTK) fusions are a large class of oncoproteins found in ~5% of cancers. Despite development of targeted therapies for cancers driven by fusion oncogenes, drug resistance remains a significant challenge, in part because we still lack a clear understanding of the broader …

    penn Repository record

  9. The Role of Axl and Axl-like Proteins in Murine Spermatogenesis

    Thompson, Kristjan LouiseEast Carolina University2009

    Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous epithelium. A sequence homology search identified an uncharacterized …

    ecu Repository record

  10. Cells and force transduction

    Rahil, ZainabUniversity of Illinois at Urbana-Champaign2019

    … but also dependent on the respective receptor tyrosine kinase (RTK) binding partner of cadherin. This involvement of RTKs at cadherin complexes is important in propagating force transduction globally, implying that force transduction at cadherin complexes is not restricted to cell-cell …

    uiuc Repository record

  11. Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan

    Fu, JiaUniversity of Illinois at Urbana-Champaign2020

    … Dzip1 on early germline development in Xenopus. Receptor tyrosine kinase (RTK) signaling is used repeatedly during Xenopus embryogenesis to establish the body plan. Ligand-independent activation of RTKs allows dissecting the receptor-specific signaling outcomes from the pleiotropic effects of the …

    uiuc Repository record

  12. Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function

    Sun, DaweiUniversity of Cambridge2020

    … targets I show that SOX9 connects WNT and receptor tyrosine kinase (RTK) signalling pathways, both of which drive lung epithelium development. SOX9 expression is regulated by canonical WNT signalling and SOX9 modulates the expression of ETV4 and ETV5, which are RTK signalling effectors, …

    cambridge Repository record

  13. Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics

    Kleiman, Laura BMassachusetts Institute of Technology2010

    The epidermal growth factor receptor (EGFR, also known as ErbB 1) is a prototypical receptor tyrosine kinase (RTK) that activates multi-kinase phosphorylation cascades to regulate diverse cellular processes, including proliferation, migration and differentiation. ErbB 1 heterooligomerizes with …

    mit Repository record

  14. DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans

    Perrin, Andrew2012

    … a single, conserved phosphatidylinositol 3-kinase (PI3K) signaling pathway that regulates somatic developmental decisions and lifespan through the Insulin-like receptor tyrosine kinase (RTK) DAF-2, the class I PI3K AGE-1 and the 3-phosphoinositide-dependent protein kinase 1 (PDK1) homologue …

    toronto-retro Repository record

  15. Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy

    Rice, Darian Clark2019

    … targeted cell surface integrin and growth factor receptors thought to be mechanically sensitive. The signaling molecules FAK, Src and ERK-MAPK are known to be triggered by integrin engagement and growth factor receptor tyrosine kinase (RTK) activation. Pairs of rat mesenteric arteries were …

    odu Repository record

  16. Modulating cell behavior with engineered HER-receptor ligands

    Alvarez, Luis M. (Luis Manuel)Massachusetts Institute of Technology2009

    … of cells to achieve desired responses. The HER receptor tyrosine kinase (RTK) family is an attractive target for manipulation of cues and signals, as its four members - epidermal growth factor receptor (EGFR or HERI), HER2, HER3 and HER4 - influence processes as diverse as development, wound …

    mit Repository record

  17. Axl RTK and microRNAs in urogenital cancers

    Fritz, HelenaTranslational Medicine2015

    … is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a …

    lund Repository record

  18. Development of novel receptor tyrosine kinase inhibitors by a chemocentric approach

    Myers, Samuel HarryThe University of Edinburgh2017

    … fewer programs being run in the manner. The AXL kinase is a receptor tyrosine kinase (RTK) and a member of the TAM family, along with MER and TYRO3. AXL has long been associated with numerous types of cancer. Having been first discovered in 1991 in acute myeloid leukaemia (AML), it has gone on to …

    edinburgh Repository record

  19. Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors

    Lin, Lu2018

    … structurally close to purines. In the design of receptor tyrosine kinase (RTK) inhibitors, Gangjee et al. have shown that properly functionalized pyrrolo[2, 3-d]pyrimidines bind to the ATP site and achieve high degrees of selectivity. This was partly attributed to the incorporation of …

    duquesne Repository record

  20. Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells

    Funk, Cory C.University of Illinois at Urbana-Champaign2011

    … the expression of three proteins: the Estrogen Receptor α (ERα), the Progesterone Receptor (PR) and Heregulin 2 (HER2). The ER, though often considered responsible for driving tumor growth, is usually indicative of a good prognosis as ER-positive tumors are typically more indolent in nature and …

    uiuc Repository record

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