Global ETD Search

Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins

Lorenzen, Emily Margaretha

<p>G protein-coupled receptors (GPCRs) are known to interact with several other classes of integral membrane proteins. However, the extent of these interactions and their role in regulating GPCR-mediated transmembrane signaling is not well understood. For example, receptor activity-modifying …

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Multiplexed Mapping of the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins

Kotliar, Ilana Beth

<p>Receptor activity-modifying proteins (RAMPs) have emerged as modulators of many aspects of G protein-coupled receptor (GPCR) biology and pharmacology. The RAMP family was discovered more than two decades ago and GPCR-RAMP interactions and their functional consequences on receptor trafficking and …

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Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor : cloning and upregulation in obstructive nephropathy

Nagae, TetsuyaKyoto University2005

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CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells

Clark, AshleyUniversity of Cambridge2020

… properties of a unique family of cell surface receptors known as G protein-coupled receptors (GPCRs), and one of their subclasses: The CGRP receptor family. These receptors are crucial for transducing information from the extracellular to intracellular space. While much pharmacological research …

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Receptor activity-modifying protein and small molecule modulation of the gastric inhibitory polypeptide receptor

Harris, MatthewUniversity of Cambridge2020

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Investigating the molecular pharmacology of class A and B G protein-coupled receptors

Carvalho, SabrinaUniversity of Cambridge2021

G protein-coupled receptors (GPCRs) possess an inherent ability to bind to an extremely diverse range of ligands and activate multiple downstream signalling pathways. It is becomingly increasingly evident, however, that for many GPCRs, the exact downstream signalling cascade(s), and the extent of …

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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors

Pearce, AbigailUniversity of Cambridge2022

Class B1 G Protein-Coupled Receptors (GPCRs) are a small family within the GPCR superfamily. However, they are implicated in the pathologies of some of the most prevalent diseases, such as type 2 diabetes and heart disease. Despite being such a small family, their signalling is very diverse; each …

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