Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Receptor Tyrosine Kinases"”.
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
The epidermal growth factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are …
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Receptor Tyrosine Kinases-Mediated Acquired Parp Inhibitor Resistance In Breast Cancer
… activations, including several hyper-activated receptor tyrosine kinases (RTKs), are involved in enhancing DNA damage repair and decreasing affinity of PARP-is to PARP1. Among the candidate RTKs, MET has more small molecules inhibitors that can target it, and thus, my colleagues and I made it a …
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Synthesis and Molecular Modeling Studies of Bicyclic Inhibitors of Dihydrofolate Reductase, Receptor Tyrosine Kinases and Tubulin
… human (hTS) and T. gondii (tgTS)</p><p> 3. Receptor tyrosine kinases: VEGFR2, EGFR and PDGFR-β</p><p> 4. Colchicine binding site of tublulin.</p><p> Novel homology models were generated and validated for pjDHFR, tgDHFR, tgTS, PDGFR-β and the F36C L65P pjDHFR double mutant. The tgTS homology …
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Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
The Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) has been established as a critical mediator of cancer-related cell signaling downstream of receptor tyrosine kinases like EGFR and HER2. As such, targeting of SHP2 is being recognized as a potentially viable therapeutic option in …
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
… metabolic augmentation. IGF-1R, much like other receptor tyrosine kinases, has been characterised as a substrate for gamma-secretase-mediated regulated intramembrane proteolysis (RIP). This proteolytic pathway begins with ectodomain shedding, mediated by sheddases, which produces a soluble …
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Nuclear Translocation of Met Via Internet Mechanism
<p>MET is one of the receptor tyrosine kinases (RTKs) that are overexpressed in malignant cancer types, including breast cancer. While RTKs are traditionally known for their roles in signaling transduction from the cell surface, recent studies have provided evidence demonstrating that most of RTKs …
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Quantitative approaches to probe the acetylproteome
… acetylation. Although the growth factors bind receptor tyrosine kinases, growth factor stimulation resulted in rapid and dynamic changes in lysine acetylation. Furthermore, we demonstrated that short-term HDAC inhibition alters phosphotyrosine-signaling networks. To better understand this …
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The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN
… in PTEN-null cells causes ER stress and loss of receptor tyrosine kinases through ER-associated degradation pathway under stress conditions. Consequently, the growth of PTEN-null cells is inhibited both in vitro and in mouse xenograft tumor models. ENTPD5 is therefore an essential component for …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… as well as for inhibition of one or more of the receptor tyrosine kinases (RTKs)- vascular endothelial growth factor receptor-2 (VEGFR2), platelet derived growth factor receptor-β (PDGFRβ) and epidermal growth factor receptor (EGFR) in single entities. Single agents with both antiangiogenic …
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Multivariate studies of receptor tyrosine kinase function in cancer
Receptor tyrosine kinases (RTKs) are critical regulators of cellular homeostasis in multicellular organisms. They influence cell proliferation, migration, differentiation, and transcriptional activation, among other processes, and are therefore also relevant to cancer biology. Upon interaction with …
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EGFR & HER2 trafficking and signaling dynamics : experimental and modeling studies
… cancers, but quantitative linkages between receptor expression levels and aberrant cell behaviors are not well understood. The ability to interpret and predict cell responses in a multi-parameter space will be vital in efforts to manipulate cell behavior for therapeutic purposes. HER2 acts …
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Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… is a truncated extracellular mutant of the EGF receptor (EGFR) that is commonly found in GBMs and confers tumorigenic behavior. Although much work has been done over the past decade to elucidate pathways involved in EGFRvIII receptor signaling, the global map of the signaling networks that it …
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Optogenetic control of developmental signaling pathways
… homo-association of plasma membrane-localized receptor tyrosine kinases.
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… Polo-like kinase 1 (PLK1) a mitotic kinase and Receptor tyrosine kinases (RTKs) which promotes metastatic behaviour. Of the majority of Eph receptors EphA2 is overexpressed in many cancers and in PDAC as well. A wealth of literature has reported an increased expression of PLK1 but therapeutic …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… development at single cell resolution. Eph receptor tyrosine kinases and their ephrin ligands play a critical role during in vivo cortical development, particularly during axon guidance. Preliminary data has shown that EphRs and ephrins are expressed during in vitro differentiation. In …
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Identification of novel components in fibroblast growth factor signalling
Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The …
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
Adaptor proteins of the Shc family link receptor tyrosine kinases (RTKs) to downstream signalling, thereby shaping cell fate decisions. While the canonical isoforms p52Shc and p46Shc act as Ras–MAPK transducers, the longer p66Shc isoform harbours an additional CH2 domain that confers distinct …
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Characterizing the Phosphorylation State of Tie2 using SH2 Domain Fusion Proteins
… in response to hypoxic conditions. The Tie receptors, Tie1 and Tie2, are receptor tyrosine kinases that are integral to angiogenic pathways. A family of Angiopoietins, Ang1-4, have been shown to act as ligands for Tie2, of which Ang1 and Ang2 are best characterized. Activation of the …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… while attempting to reach their targets. EphB receptor tyrosine kinases direct axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to bidirectional signals, the contributions of signaling into the Eph-expressing cell …
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