Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Receptor Localisation"”.
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
… potential is compromised. The nuclear receptor RXR$\gamma$ is an important positive regulator of OPC differentiation and an accelerator of endogenous remyelination in aged rats. RXR$\gamma$ functions as a ligand-induced transcription factor and is able to regulate gene transcription. It …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor provides a tractable therapeutic target for multiple cardiovascular diseases, …
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The Octopaminergic Modulatory Circuitry of the Drosophila Larval Mushroom Body Calyx
… circuit express different neuromodulatory receptors for differential modulation. Here I aimed to use the simple and genetically amenable Drosophila larval Mushroom Body (MB) calyx, a higher order processing area involved in learned odour discrimination, as a model to map octopamine (OA) …
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Re-evaluation of the in vitro activity of the protease activated receptor-1 (PAR1) pepducin PZ-128
… prevent thrombus formation. Protease-activated receptor 1 (PAR1) is a key target due to its role in thrombin-mediated platelet activation.;PZ-128 is a cell penetrable pepducin that targets PAR1 and has entered phase II clinical trials, however, adverse effects in trial subjects have emerged that …
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An Investigation into the pharmacology of the ghrelin receptor
The ghrelin receptor (GRLN-R) was cloned in 1996 after the discovery that a series of synthetic growth hormone-releasing compounds (the growth hormone secretagogues) acted through a receptor distinct from the growth hormone-releasing hormone receptor. In 1999 the endogenous ligand of the receptor, …