Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Receptor, trkB"”.
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… in DA release is not mediated by DA D3 autoreceptors. Meanwhile, chronic toluene exposure attenuated DA release only in the nucleus accumbens (NAc). Repeated toluene exposure also increased extracellular DA levels in the NAc, which is typical of addictive drugs. However, repeated toluene …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… expression, and required specific estrogen receptor isoforms, as demonstrated using estrogen receptor knockout mice. Immuno-electron microscopy revealed that estradiol specifically increased signaling through presynaptic TrkB receptors in Schaffer collateral and mossy fiber axons. Estradiol …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing evidence suggests that BDNF/TrkB facilitates LTP in part through the stimulation of Rho GTPases and subsequent F-actin remodeling …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… via signaling through the truncated tropomyosin receptor kinase B (TrkB) receptor. TrkB is the primary receptor for BDNF which is broadly expressed and released by neurons in developing and mature brain. TrkB has two predominant isoforms expressed in central nervous system (CNS), the full length …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
Ketamine is a N-methyl-D-aspartate receptor (NMDAR) antagonist that elicits rapid antidepressant responses in depressed patients. However, ketamine can also produce psychotomimetic effects, which limits its widespread use. The field has been exploring the mechanism of ketamine's antidepressant …
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PLASTIC CHANGES IN THE INHIBITORY GLYCINE SYSTEM OF THE DORSAL COCHLEAR NUCLEUS (DCN) IN A RAT MODEL OF TINNITUS
… protein levels of &alpha<sub>1-3</sub> glycine receptor subunits (GlyRs), gephyrin, BDNF and its receptor TrkB were assessed in dorsal cochlear nucleus (DCN) fusiform cells 4 months post exposure utilizing quantitative in situ hybridization and immunocytochemistry. Young exposed rats showed …
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TrkB and gene expression
… 4/5(NT4/5). Neurotrophins bind the Trks receptor family (TrkA, B, C). NGF is the preferred ligand for TrkA, BDNF and NT4/5 are preferred for TrkB, and NT3 for TrkC, although NT3 also binds with less affinity to TrkA and TrkB. During my PhD I have focused my interest in understanding how …
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Role of BDNF secretion and signaling in the activity-dependent refinement of synaptic connections
… as well as ditribution of their cognate receptors are of crucial importance. In the first part of this doctoral thesis I have used electrophysiological approaches and real-time imaging tecniques to investigate additional features about the regulation of neurotrophins secretion, namely the …
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… synaptic plasticity, signalling via its major receptor, Tyrosine receptor kinase B (TrkB). In the developing brain, BDNF acts as a guidance cue influencing the direction of the axonal growth cone. In the mature brain, it ensures survival of neurons and synaptic plasticity. Guidance cues remodel …
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BDNF-TrkB Signaling in Efficacy of CA3-CA1 Synapses and Ketamine-Mediated Antidepressant Effects
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Role of Tyrosine Receptor Kinase B in the Development and Function of the Central Nervous System
Tyrosine Receptor Kinase B (TrkB) was initially identified as the high-affinity receptor for Brain-Derived Neurotrophic Factor (BDNF) in regulating the survival of sympathetic and sensory neurons. In the CNS, however, BDNF-TrkB interaction has been shown to regulate diverse aspects of development, …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
… increases in BDNF also lead to activation of its receptor, tropomyosin receptor kinase B (TrkB). Studies indicate that the loss of TrkB specifically in the NAc shell reduced the reinforcing effects of cocaine using a self-administration paradigm, and also psychomotor effects of cocaine on …
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A Role for BDNF-Trkb Signaling in the Modulation of Superoxide Dismutase-1 Expression
… via a cDNA expression screen, that the TrkB receptor and the guanine nucleotide exchange factor, RasGRF-1, modulate SOD1 expression at the protein level, suggesting that cell signaling pathways associated with TrkB signaling are involved in regulating the expression of SOD1. …