Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 6982 for “"Receptor"”.
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Receptor
… an extension for receptions ergo the name Receptor.
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in …
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Characterisation of a novel leukocyte receptor complex-encoded receptor TARM1
… inhibitory signals transmitted by cell surface receptors. Perturbations in this balance by overamplified or dysregulated signalling underlie many severe immunopathologies such as sepsis and cancer. In this work I describe the identification and characterisation of a novel, evolutionarily …
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Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
The dopamine D1 receptor (D1R) is a G protein-coupled receptor that signals through Gs and Golf G proteins. D1R agonists increase cAMP production and recruit β-arrestin to the plasma membrane, which may lead to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is …
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Chemical Approaches to Inhibiting the Estrogen Receptor-Steroid Receptor Coactivator Interaction
… unfortunately, only weakly bind to the estrogen receptor a.
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
… of synthesis and degradation of steroid hormone receptors are crucial factors in maintaining hormone responsiveness in target tissues. It was the intent of this study to determine the turnover of the estrogen receptor (ER) and progesterone receptors (PR) in rat uterine and human breast cancer …
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Analyzing the Interaction Between Melanocortin 5 Receptor, Melanocortin Receptor Accessory Protein 1, and Melanocortin 2 Receptor in Rainbow Trout
… the functional relationship of rainbow trout MC5 receptor (rtMC5R) with zebrafish MRAP1 (zfMRAP1) and rainbow trout MC2 receptor (rtMC2R), as well as how the effect of such relationships may play a significant role in Hypothalamic-Pituitary-Adrenal/Interrenal axis activation. This research …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative …
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Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
… cancer cells often overexpress the estrogen receptor protein. By synthesizing a drug that not only binds and damages the DNA but also binds the abundant proteins in the cells, thereby blocking the damaged site from DNA repair proteins, a selective treatment of cancer cells can be achieved. In …
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated …
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… ligand activated transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this pathway …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …
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Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor
… has not been determined via their target steroid receptor (SR), the progesterone receptors and its isoforms (PR-A and PR-B). This thesis involves an in vitro investigation of some of the factors that affect PR activity and that may thus impact progestogen responses in women on HC or HRT. These …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
… as it functions as an antagonist at cannabinoid receptor 1 (CB1). However, recent evidence suggests that CBD may also be a CB1 negative allosteric modulator of (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC). Interestingly, the ECS is linked to the main circuit thought to modulate reward signaling …
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Olfactory Receptor Antagonism in the OR-I7 Aldehyde Receptor and the Mammalian Olfactory System
… when an odorant binds and activates olfactory receptors (ORs) within the nose. Chapter 1 studies the structural requirements for activation of the OR-I7 aldehyde receptor. Octanal is an agonist of the OR-I7 receptor. 4-Ethylcyclohexylacetaldehyde (<strong>1.1)</strong>, with a cyclohexyl ring …
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Biochemical and Biophysical Studies on the Human Estrogen Receptor and Receptor Co -Regulator Interactions
These results are consistent with proposed ER-LBD/SRC-1 interaction and further the understanding of the tissue selective pharmacology seen with estrogenic and anti-estrogenic compounds.
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Synthesis towards synthetic adenosine receptor
… However its selective detection by synthetic receptors is not possible till date. Efforts have been made here to design molecular tweezer for adenosine. Multistep synthesis was done to synthesize two clamps, namely the [pi]-[pi] stacking clamp and the hydrogen bonding clamp for the proposed …
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