Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Reassortment"”.
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Reassortment of bluetongue virus vaccine serotypes in cattle
… has been reported previously. In 1987, reassortment was investigated in cattle between BTV serotypes 11 and 17 where six reassortants with unique genetic profiles were described. In 2008, in Europe, segment 5 of BTV serotype 16 was identical to the South African vaccine strain of BTV …
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
… My central hypothesis is that genetic reassortment or recombination between two phleboviruses can occur when a loss or swap of gene element does not deteriorate the viability of resulting viruses. The overall objective of this study is to analyze genetic reassortment or recombination …
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Exploring the phylodynamics, genetic reassortment and RNA secondary structure formation patterns of orthomyxoviruses by comparative sequence analysis
… that there is no difference in the frequency of reassortments among the segments that constitute influenza virus genomes; and (2) that there is epochal temporal reassortment among influenza viruses and that all geographical regions are equally likely sources of epidemiologically important …
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Characterizing the effect of mutation recombination and reassortment on the genetic diversity of African horse sickness virus genomes
… potentially undergo genetic recombination and reassortment during the co-infection of the same host cells by at least two different virus strains of the same species. Since it is an arbovirus, we proposed that the virus would evolve slower than other RNA viruses that require a single host for …
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Identification of reassortant influenza viruses at scale : algorithm and applications
Reassortment is a reticulate evolutionary process that results in genome shuffling; the most prominent virus known to reassort is the influenza A virus. Methods to identify reassortant influenza viruses do not scale well beyond hundreds of isolates at a time, because they rely on phylogenetic …
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Phylogenetic approaches for quantifying the genotypic diversity of influenza viruses
… by high frequencies of co-infection and segment reassortment. The recently emerged avian influenza viruses that spilled-over into the human population were all produced by dynamic reassortment between wild bird viruses and poultryadapted H9N2 viruses. The recruitment of poultry-adapted internal …
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Virologic Factors Contributing to the Genetic Diversification of Influenza Viruses Circulating in North American Swine
… of this study was to determine mechanisms of reassortment of swine influenza viruses and determine if certain reassortant gene combinations can drive evolution and host adaptation in the context of the triple reassortant internal gene (TRIG) cassette. The TRIG contains a unique combination of …
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Pandemic Potential of Reassortant Swine Influenza A Viruses
… been implicated as a “mixing vessel” for the reassortment of influenza A viruses from different species. The reassortment of influenza A viruses of human and avian origin led to human influenza pandemics in 1957 and 1968.</p> <p>The dynamics of swine influenza viruses in North America changed …
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USING SINGLE VIRION FUSION ASSAY TO STUDY INFLUENZA VIRUS ENTRY
… (i.e. error-prone RNA replication, influenza reassortment, and influenza recombination). Influenza virus mutation mechanisms may cause the emergence of new strains, some of which may lead to serious flu pandemics in humans. Understanding the fusion fitness of influenza strains at the …
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Influenza Dynamics from Pre-pandemic to Post-pandemic Periods: Epidemiology and Genetic Characteristics
… also identified a high frequency of interclade reassortment events between subclades 3C.2a1b.2a.2 and 3C.2a1b.1a, previously unreported in Australia. Furthermore, Bayesian phylogeographic analysis elucidated the spatiotemporal spread of A/H3N2 viruses within Australia during this season. These …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… occurring viral reassortants and in vitro reassortment experiments demonstrate segment segregation preferences amongst the RNA segments during replication and/or packaging. Viral reassortants were utilized to investigate the viral genome segment(s) responsible for hamster lethality, this …
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Network and Algebraic Topology of Influenza Evolution
… chapter of my thesis examines how mutations and reassortment combine to alter the course of influenza evolution towards pandemic formation. I highlight inherent deficiencies in the current phylogenetic paradigm for analyzing evolution and offer a novel methodology based on algebraic topology that …
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Past Environmental Change On The Eastern Andean Flank, Ecuador
… Fire was not the main driver for the vegetation reassortment at either site (MTW correlation coefficient: -0.37, MTE: 0.16). The two sites have demonstrated the EAF plays host to floristically dynamic ecosystems, susceptible to drivers of change (fire and landscape) and should be considered when …
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Phase Separation Mediated Compartmentalisation of Rotavirus Replication
… as a mechanism to coordi- nate rotavirus strain reassortment, as co-infection of different strains does not lead to mixing of different RNAs, as shown using in situ hybridisation techniques. Together, these findings establish LLPS as the organising principle of rotavirus replication factories and …
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Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus
… its replication might be pH independent.</p> <p>Reassortment of orthomyxoviruses is a known mechanism of pandemic emergence of IAV and an informal proxy for genus distinction with viruses from distinct genera considered unable to successfully reassort. Contradictory to published data using …
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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution
… of interferon also permitted greater rates of reassortment. Together, this suggested obesity permitted the emergence of novel, and potentially pathogenic, viral variants. Influenza viruses pose constant seasonal and pandemic threats with high morbidity and mortality suffered by overweight and …
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Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
… virus replication, virus evolution, and genetic reassortment. However, the mechanisms of viral RNA packaging in RVFV and other bunyaviruses are largely unknown. To study the accumulation kinetics and packaging profile of RVFV RNAs into virions, we established a novel strand-specific RT-qPCR assay …
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Investigation of Swine Influenza Virus Genetic Diversity and Evolution
… of swine influenza virus (SIV) co-circulate. The reassortment of viral RNA segments in cells infected by multiple viruses can lead to a sudden shift in antigenicity. One such reassortant virus, the pandemic H1N1 (pH1N1) influenza virus was first reported in humans in the spring of 2009 and soon …
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A tool of "barcoded viruses" to study influenza virus transmission dynamics
… with virus aggregation during release). Reassortment was found to occur efficiently and ubiquitously when near-isogenic viruses co-infected cells. The timing of asynchronous co-infection revealed that super-infection was possible if the second virus encountered the cell within 4 hr of the …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
… as a result of coinfection and segment reassortment between CVV lineages, reassortant isolates have emerged and has increased the genetic diversity of this virus. Importantly, recent case reports in humans have been associated with infection by these reassortant CVV strains. Pathogenesis …
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