Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Read lengths"”.
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Empirical accuracy bounds for next-generation sequencing variant calling workflows
… variant detection accuracy in a workflow. Short read sequencers are inherently incapable of producing reads that can be uniquely mapped to every position of the human reference genome, so errors are inevitable. We will analyze the repetitive content of several organisms, and estimate the maximum …
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A Quantitative Exploration of Causes of False Positive Single Nucleotide Polymorphisms in Next-Generation Sequencing Data
… approach to SNP discovery is based on mapping reads to a reference sequence. Apart from sequencing errors, which vary in pattern and rate depending on the sequencing platform, the short read lengths that prevail in NGS, together with the repetitive nature of the genomes of many organisms, can …
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A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders
… strategies, including probe targeting and NGS read length, were investigated. NGS-capture was shown to accurately detect clonal VDJ recombination by targeting one side of the rearrangement and using lower read lengths, down to 75 bp.<br/><br/>NGS SHM analysis using the 1.5 kb genomic sequence …
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Next-Generation Approaches to Understanding the Diversity and Evolution of Marine Fungi
… an attempt to advance our understanding of the breadth of fungal diversity, to establish a broader evolutionary context for marine fungi, and to provide some molecular tools to better study marine fungi that have, until now, eluded our detection.</p><p>In Chapter 1, I investigate the diversity …