Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Reactive oxygen and nitrogen species"”.
-
Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation
… disease. Reperfusion is the restoration of an oxygenated blood supply to hypoxic tissue and can cause more cell injury. The kinetics and consequences of reactive oxygen and nitrogen species (ROS/RNS) production in cardiomyoblasts are poorly understood. The present study describes the systematic …
-
Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
Nitrate is the most common ionic form of nitrogen in aquatic ecosystems. Although nitrate is known to affect ecosystems at high levels through eutrophication, hypoxia and loss of biodiversity, it is considered to be physiologically inert to the individual aquatic organism. To test the physiological …
-
The utilization of boron-rich clusters as aids to detect reactive oxygen and nitrogen species through non-fluorescent modalities
Reactive oxygen and nitrogen species (ROS/RNS) are small, highly reactive, and transient oxygen/nitrogen containing compounds that play important roles in redox signaling processes to maintain cellular homeostasis. Typically, these finnicky species are detected through activity-based sensors (ABS) …
-
Coping with stress: How Reactive Oxygen and Nitrogen Species alter the transcriptional landscape of the Lyme disease spirochete Borrelia burgdorferi
… infect its tick vector Ixodes scapularis and various mammalian hosts. Lipoprotein expression is controlled by a limited number of transcription factors in response to environmental challenges encountered during infection, including changes in pH, temperature, osmolarity, and nutrient …
-
The molecular basis for tumor growth suppression by tRNA methyltransferase 9-like (TRM9L)
… 9-like (TRM9L) gene is a homolog of yeast Trm9 and human ALKBH8 and it has an important function in suppressing tumor growth in colorectal cancer. Loss of heterozygosity events on the Chromosome 8p22 loci, where TRM9L is located, are overrepresented in a wide variety of cancers, including …
-
Quantitative Proteomic Methodology Use and Development to Characterize Ethanol Modulation of Microglial Function
… can be either neurotoxic, through the release of reactive oxygen and nitrogen species and inflammatory cytokines, or neurotrophic. Microglial activation due to chronic ethanol exposure has been implicated in neuroinflammation. We use mass spectrometric metabolic labeling techniques to explore and …
-
Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair
<p>DNA double strand breaks (DSBs) are very deleterious events that occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or …
-
Mechanisms of anaerobic nitric oxide detoxification by Salmonella enterica serovar Typhimurium
Salmonella is the cause of millions of food- and water-borne infections worldwide. Systemic infection and gastroenteritis are the main diseases and often prove fatal to immunocompromised patients. Key to Salmonella’s pathogenicity is the survival of several components of the innate immune system …
-
Cellular and acellular assays for measuring oxidative stress induced by ambient and laboratory-generated aerosol
… through PM-initiated production/release of reactive oxygen and nitrogen species (ROS/RNS). This dissertation explores cellular and acellular measurements of PM-induced oxidative stress through systematic laboratory chamber experiments and ambient field studies. A cell-based assay involving …
-
Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… by the selective degeneration of spinal and upper motor neurons. One approach in the development of therapies for ALS is to explore the potential of human fetal neural stem cells (hNSCs) to replace lost motor neurons. The therapeutic efficacy of stem cell transplantation would depend …
-
Biogenesis and Redox Transition of Iron-sulfur Clusters in Proteins
… proteins comprise one of the most ubiquitous and conserved classes of proteins in biology. The diverse functions of iron-sulfur clusters in proteins range from electron transfer to redox signaling. The assembly of iron-sulfur clusters in cells requires a complex protein system and acquisition …
-
Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… cognitive deficits, specifically in learning and memory. Typically known for its role in muscle relaxation and contraction, the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is also highly expressed in the brain and therefore is suspected to play a role in the regulation of neuronal Ca2+. …
-
XRCC1 & DNA MTases : direct and indirect modulation of inflammation-induced DNA damage
… the molecular interactions at play. Inflammatory reactive oxygen and nitrogen species (RONs), including peroxynitrite and nitric oxide (NO'), may potentiate malignancy. We hypothesize that the base excision repair (BER) pathway modulates susceptibility to malignancy, by modulating the …
-
The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… cell arising from the increased generation of reactive oxygen and nitrogen species and/or a decrease in the ability of the cell to scavenge and detoxify the reactive intermediates. Strong evidence supports the notion that oxidative stress serves as an important mediator in leading to …
-
The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… cell arising from the increased generation of reactive oxygen and nitrogen species and/or a decrease in the ability of the cell to scavenge and detoxify the reactive intermediates. Strong evidence supports the notion that oxidative stress serves as an important mediator in leading to …
-
Cerium oxide Nanoparticles: Their Phosphatase Activity and its Control
… nanoparticles are established scavengers of reactive oxygen and nitrogen species. They have many potential biomedical applications that depend on their physicochemical properties and mode of preparation. Recent studies have found these nanoparticles possess phosphatase mimetic activity. …
-
Turn-on fluorescent probes for detecting nitric oxide in biology
… the Biological Roles of Nitric Oxide and Other Reactive Nitrogen Species Using Fluorescent Probes: This chapter presents an overview of recent progress in the field of reactive nitrogen species (RNS) sensing. Reactive nitrogen species, such as nitric oxide (NO) and its higher oxides, …
-
The dynamic interplay between DNA damage and metabolism : the metabolic fate and transport of DNA lesions and novel DNA damage derived from intermediary metabolism
… work presented in this thesis explores two novel and complementary facets of endogenous DNA damage: the development of biomarkers of inflammation based on metabolites of DNA damage products and the formation of DNA adducts by electrophilic products of intermediary metabolism. From the first …