Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Reactive nitrogen species (RNS)"”.
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Energy-producing ability of bacteria under oxidative stress
Nitrosative stress is caused by reactive nitrogen species (RNS) and is toxic to most organisms. RNS are generated by the immune system to combat infectious microbes and are known to impede O2-dependent energy production. The goal of this study was to elucidate alternative adenosine triphosphate …
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Quantitative Proteomics Analysis of Differentially Expressed Proteins in Aβ(17-42) Treated Synaptosomes
… low levels of antioxidant defense systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can react with biomolecules such as proteins, lipids, carbohydrates, DNA, and RNA, which can lead to oxidative damage, cellular dysfunction, and can ultimately cause cell death. Down …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… astroglial myeloperoxidase (MPO), and subsequent reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and oxidative DNA damage in the MPTP-treated substantia nigra. Additional immunohistochemical staining also showed that MPTP induced glial cell line-derived neurotrophic factor …
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The Role of Mitochondrial Alternative Oxidase in Plant-pathogen Interactions
… has been hypothesized to modulate the level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in plant mitochondria. The aim of the research presented herein is to provide direct evidence in support of this hypothesis and to explore the implications of this during …
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Adaptation of Candida albicans to Reactive Sulfur Species
… stresses. This includes stress caused by reactive sulfur species (RSS), such as sulfite, produced by C. albicans, sulfate-reducing commensal microbes, and the host immune system. From a collection of transcription factor deletion mutants, only the mutant lacking the zinc cluster factor …
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The Role of IRAK-1 in the Regulation of Free Radicals and Oxidative Stress during Endotoxemia
… of many chronic and acute inflammatory diseases. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are two key mediators that are known to induce cellular and tissue oxidative stress. The generation of ROS and RNS is mediated by innate immune signaling processes. Lipopolysaccharide …
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
… function due, in part, to the generation of reactive oxygen (ROS) and reactive nitrogen species (RNS) (e.g. peroxynitrite, ONOO‾). Although blast TBI (bTBI) also reduces cerebral perfusion, less is known about other cerebral vascular effects of bTBI. To determine the effects of mild bTBI on …
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Neuroprotective effects of gamma-glutamylcysteine ethyl ester on an in vivo moderate traumatic brain injury-mediated model and in vitro in cortical astrocytes and neurons
… of intracellular redox homeostasis by scavenging reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this thesis, we attempted to evaluate the abilities of a GSH precursor, gamma-glutamylcysteine ethyl ester (GCEE), to prevent neurodegeneration by combating intracellular …
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Post-Translational Modification of Proteins via Ambient Air Pollutants and Endogenous Reactive Species
<p>Proteins can react with reactive oxygen species (ROS) and reactive nitrogen species (RNS) to form post-translational modifications (PTMs), which can affect protein structure and function. The formation of 3-nitrotyrosine (NTyr) and dityrosine (DiTyr) upon reaction of proteins with ROS/RNS are …
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Nitrogen oxide delivery systems for biological media
… These processes are likely mediated by reactive nitrogen species (RNS) such as nitrogen dioxide (NO2) and peroxynitrite formed from the respective reactions of NO with oxygen and superoxide anion. Controlled delivery of these RNS at levels expected to occur in vivo is desirable in …
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DEVELOPMENT OF MICROCHIP ELECTROPHORESIS BASED METHODS TO PROFILE CELLULAR NITROSATIVE STRESS
Nitric oxide (NO) is the main reactive nitrogen species (RNS) produced by immune cells. NO reacts with superoxide to produce peroxynitrite (ONOO-). These two RNS are capable of nitration, nitrosylation and oxidation of intracellular biomolecules that can alter various biochemical processes. To help …
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Coping with stress: How Reactive Oxygen and Nitrogen Species alter the transcriptional landscape of the Lyme disease spirochete Borrelia burgdorferi
… B. burgdorferi encounters host-derived reactive oxygen species (ROS) and reactive nitrogen species (RNS) during infection of I. scapularis ticks, which we hypothesize also serve as signals sensed by B. burgdorferi to modulate gene expression. We tested this hypothesis by determining …
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Uncovering the Redox Potential of the Global Gene Regulatory Protein DksA in Borrelia burgdorferi
… burgdorferi involves transmission between Ixodes species tick vectors and vertebrate hosts. This infectious cycle requires the spirochetal bacteria to undergo dramatic shifts in gene expression in order to survive and remain virulent. Currently, it is unclear how B. burgdorferi senses the relevant …
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Proteome Profiling of Saccharomyces cerevisae stress response to Cumene Hydroperoxide (CHP)
… diseases. Stress studies have shown that reactive oxygen species (ROS) and reactive nitrogen species (RNS) along with its intermediates can attack essential cell targets such as: DNA, proteins, lipids and carbohydrates, leaving behind dysfunctional biologic molecules. In effect, a cell's …
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Prediction of concentrations of reactive nitrogen species in aqueous solutions and cells
Reactive nitrogen species (RNS) derived from nitric oxide (NO) have been implicated in cancer and other diseases, but their intracellular concentrations are largely unknown. To estimate them under steady-state conditions representative of inflamed tissues, a kinetic model was developed that …
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Turn-on fluorescent probes for detecting nitric oxide in biology
… the Biological Roles of Nitric Oxide and Other Reactive Nitrogen Species Using Fluorescent Probes: This chapter presents an overview of recent progress in the field of reactive nitrogen species (RNS) sensing. Reactive nitrogen species, such as nitric oxide (NO) and its higher oxides, play …