Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Reactive astrogliosis"”.
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Cyclic AMP and the Induction of Reactive Astrogliosis
… (proliferation), a process referred to as reactive astrocytosis. Reactive astrogliosis can be modeled in vitro using mechanical (scratch wound) or chemical stimuli to activate F98 rat glioblastoma cells from a quiescent state to a reactive-like state. Studies have shown monoclonal antibody …
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Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
… upregulated, edema was prominent, and reactive astrogliosis occurred. When siAQP4 was administered after jTBI, there was functional improvement, decreased edema, and decreased reactive astrogliosis. When siCx43 was administered, there was functional improvement and decreased reactive …
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Endosomal Trafficking and Exosomal Secretion of Egfrviii
… exosomes induce changes in astrocytes that mimic reactive astrogliosis including an increase in glial fibrillary acidic protein (GFAP) and altered astrocyte morphology.</p> <p>These results reveal novel aspects of the endocytic trafficking of EGFRvIII that underlie its reduced degradation and the …
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Role of JAK2 in the Proliferation of Activated Astrocytes
… by increased expression of GFAP. Although reactive astrocytes have some regenerative properties, the astrogliosis is thought to be a barrier to repair in the central nervous system. The activated astrocytes secrete many types of cytokines and inflammatory mediators, which might be …
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Generation of focal Depdc5 knockout mouse model and implications for focal epilepsy
… region are identified, such as hypomyelination, reactive astrogliosis, and microglial activation. Our focal Depdc5 knockout mouse model recapitulates clinical, pathological, and biochemical features of human DEPDC5-related epilepsy and brain malformations. Our study reveals that postnatal DEPDC5 …
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A STUDY ON THE BIOCHEMICAL AND CELLULAR EFFECTS OF ENVIORMENTAL TOBACCO SMOKE ON ADULT AND DEVELOPING RAT BRAIN BIOCHEMISTRY
… ETS exposure study, we focused on markers of astrogliosis , oxidative stress, and cell death. We observed altered GFAP suggestive of reactive astrogliosis. Yet, markers of oxidative and cell stress were unaffected by ETS exposure in the brain regions examined. Increased degradation of …
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Nano-engineered polymers in drug delivery: Potential approaches for attenuation of secondary injury after spinal cord trauma
… an up-regulation of glial cells associated reactive oxygen species, nitrogen species, and reactive astrogliosis, and they can result in various levels of cellular and tissue damage. The inhibition of them has been proved to lead to functional recovery of the spinal cord. In this study, we …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… but are not limited to, inflammation, ischemia, reactive astrogliosis and apoptosis. These mechanisms contribute to tissue degeneration and limit neural regeneration and repair after injury. To optimize future therapeutic approaches, it is necessary to identify factors that regulate the early …
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The Neuroprotective and Therapeutic Effects of Anthocyanins and Their Metabolites In Vitro and in a Mouse Model of Amyotrophic Lateral Sclerosis
… histopathological indices of disease, reducing reactive astrogliosis in lumbar spinal cord tissue, and preserving neuromuscular junctions in gastrocnemius muscle tissue. We next illustrate that phenolic acid metabolites derived from anthocyanins display distinct and complimentary neuroprotective …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… the spinal trigeminal nucleus, with no signs of reactive astrogliosis. We also demonstrated that the expression levels of the microglial P2Y12 receptor do not change following CFA injections. In conclusion, this in vivo model represents a useful tool for evaluating the role of specific P2Y …