Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 916 for “"Reactive Oxygen Species"”.
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Reactive Oxygen Species-Induced Necrotic Cell Death
… (TGHQ), a reactive oxygen species (ROS) generating nephrotoxic and nephrocarcinogenic metabolite of hydroquinone, causes necrotic renal cell death, the basis for which is unclear. We therefore investigated TGHQ-mediated cell death in human renal proximal …
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A Role For Reactive Oxygen Species In Photodynamic Therapy
… the photosensitizer was transferred to dissolved oxygen to form singlet oxygen. This product has a very brief half-life and will cause cellular damage only in the immediate vicinity of its formation. But an excited-state photosensitizer can also interact with oxygen to form superoxide anion …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the development and maintenance of neuropathic pain. However, it is not known whether oxidative stress is related to the loss of GABAergic tone in the spinal cord. Therefore, the major goal of …
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Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism
… mechanism involves the metabolic production of reactive oxygen species (ROS), which can damage proteins, lipids, and nucleic acids, and can ultimately result in bacterial cell death. The body of work described here shows that this common mechanism can be exploited to improve antibiotic activity, …
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The effect of reactive oxygen species on aged skeletal muscle
The production of reactive oxygen species (ROS) may be a contributor to the progression of sarcopenia. Sarcopenia is a generic term for the loss of skeletal muscle mass, quality and strength. ROS are usually produced by radiation, but are also the byproducts of aerobic metabolism. ROS have been …
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DISSECTING THE ROLE OF REACTIVE OXYGEN SPECIES IN EARLY MAMMALIAN EMBRYOGENESIS
Reactive oxygen species (ROS) comprise a broad spectrum of molecules that are known to induce oxidative stress (OS) in both gametes and embryos. OS arises when ROS production exceeds a critical threshold, or when intracellular antioxidant systems are unable to neutralize them effectively. OS is a …
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Reactive Oxygen Species and P21 Waf1/Cip1 Are Both Essential For
… in HNSCC, through its ability to regulate reactive oxygen species (ROS). With the use of a novel system to evaluate the impact of the <em><em>TP53 </em></em>missense mutations, we were able to distinguish that cells with a partially functional <em>TP53</em>, that are resistant to radiation …
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Mitochondrial metabolic suppression and reactive oxygen species production during hypometabolism in mammals
… metabolic suppression affects mitochondrial reactive oxygen species (ROS) production, a topic which has been largely ignored previously. To accomplish these objectives, I measured in vitro respiration and ROS production rates of mitochondria from liver, skeletal muscle, and/or heart during …
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Role of Reactive Oxygen Species and Altered Biochemical Pathways in Cellular Aging
No abstract prepared.
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How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
… life. Historically, mitochondrial generation of reactive oxygen species (ROS) was considered to be an unregulated process, produced by dysfunctional mitochondria. More recently, mitochondrial ROS generated by complex I, particularly by the process of reverse electron transfer (RET), has emerged …
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Novel Methods to Characterise Atmospherically Relevant Organic Radicals and Reactive Oxygen Species
… accepted that this reaction proceeds via a reactive intermediate often called the Criegee intermediate (CI). This reaction is known to produce a plethora of oxidised organic compounds, which contribute to ozone formation and secondary organic aerosol production, two of the main …
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
… protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the …
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Role of IRAK-1 in the Dynamic Regulation of Reactive Oxygen Species
Generation of reactive oxygen species (ROS) by mammalian host cells is a double-edged sword. ROS are clearly beneficial in directly killing pathogens and as a signaling molecule to alert macrophages and neutrophils to the site of infection. However, ROS are also capable of damaging host cells by …
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Nanoclusters for Cancer Therapy: Assesment of Their Reactive Oxygen Species Generation and Stability
… absorb light and use this energy to generate reactive oxygen species, resulting in targeted cancer cell death. To be an effective photosensitizer, clusters must have long-lived excited states that can interact with oxygen to produce reactive oxygen species. This interaction between the excited …
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The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… also functional myoendothelial gap junctions. Reactive oxygen species (ROS) have been implicated in the response, but their precise role remains uncertain. To investigate this, the cremaster muscle circulation of freshly killed rats was perfused with a Krebs buffer solution containing albumin …
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The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… (DCF-DA) was used to quantify reactive oxygen species during venom stimulation. HEK cells stimulated with 50μg/ml <em>Crotalus atrox </em>venom resulted in a 336-fold increase in ROS-induced fluorescence between 1 and 2 hours (p<0.001). Pre-treating the cells with 200 Units …
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Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy
… Furthermore, this study used conjugation of reactive oxygen species (ROS) sensitive moiety which triggered the release of incorporated drugs in response to ROS in DR. Beta-cyclodextrin was conjugated with a ROS sensitive moiety (Ox-β-cyclodextrin), 4-(hydroxymethyl) phenylboronic acid pinacol …
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Cellular Mechanisms of Resveratrol's Interaction with Mitochondrial Reactive Oxygen Species Metabolism
Resveratrol, a polyphenol found naturally in red wines, has attracted great interest in both the scientific community and the general public for its reported ability to protect against many of the diseases facing Western society today. While the purported health effects of resveratrol are well …
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