Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Reactive Gliosis"”.
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
The process of astrogliosis, or reactive gliosis, is a typical response of astrocytes to a wide range of physical and chemical injuries. The up-regulation of the astrocyte specific glial fibrillary acidic protein (GFAP) is a hallmark of reactive gliosis and is widely used as a marker to identify …
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From mice to men - astrocytes and neural progenitor cells in neural plasticity and regeneration
… or neurodegenerative diseases, astrocytes become reactive, which is known as reactive gliosis. Two characteristic hallmarks of reactive gliosis are hypertrophy of astrocyte processes and up-regulation of the intermediate filament (also known as nanofilament) proteins GFAP, vimentin, nestin and …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… receptors resulting in an attenuation of reactive gliosis and the production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of these studies was to determine the involvement of OPN and an RGD containing peptide in the regulation of …
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A Glial Role in the Action of Electroconvulsive Therapy
… We also demonstrate that ECS, without inducing reactive gliosis (a hallmark of brain damage), increase glial cell activity. Given that glial cells (by supporting, communicating with and nourishing the surrounding neurons) play a vital role in neuronal network, we hypotehesize that these glial …
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Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… of the mammalian retina respond to injury with reactive gliosis, which if persistent, can lead to loss of Müller cell function and devastating vision loss. Despite this, multiple lines of evidence suggest that mammalian Müller glial cells possess a latent ability to regenerate retinal neurons. …
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In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
… material into the CNS can lead to a strong reactive gliosis re-sponse from endogenous astrocytes and microglia. Surprisingly, not only did the RGDS-peptide amphiphile not elicit a stronger glial response than the control needle wound injury, but it rather suppressed the reactivity of …
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Genetic Networks Modulating Retinal Injury
… Egr1 define the early response, whereas, glial reactive markers such as Gfap and Cd81 define the sustained response. Second, three specific genomic loci modulate coordinated changes in gene expression in mouse brains: regulatory loci on chromosomes 6, 12, and 14. Of the three only the regulatory …
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Cognitive, Psychiatric, And Neuropathological Manifestations Of Repetitive Mild Traumatic Brain Injury
… The neuropathological outcomes of rmTBI included reactive gliosis, axonal degeneration, elevated levels of Aβ (1-42), β-amyloid, p-tau, TDP-43, and significant thinning of several white matter tracts. Notably, these outcomes occurred in mice receiving head impacts that did not delay recovery of …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… progressive loss of motor neurons (MNs) and astrogliosis. Recent evidences suggest that factors secreted by activated astrocytes might contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide which is strongly up-regulated in reactive astrocytes under different pathological …