Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Reaction discovery"”.
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New methodologies and approaches to reaction discovery in transition metal catalysis
… Although high-throughput methods for catalyst discovery that would mirror related approaches for the discovery of medicinally active compounds have been the focus of much attention over the past fifteen years, these methods have not been sufficiently general or accessible to typical synthetic …
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Advances in synthetic methodology: Dearomative aminofunctionalization of arenes and high-throughput reaction discovery
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Data-rich experimentation and computer-aided strategies in reaction discovery, selectivity optimization, and structure elucidation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Novel reaction discovery with rapid high-throughput experimentation via infrared spectroscopy and enzymatic electrochemical oxidation of alcohols
… is to incorporate environmentally benign reaction design into routine and novel synthesis in order to minimize the use of toxic substances and waste while maximizing the overall efficiency of reaction processes. Both projects reported here encompass the idea of sustainability and …
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Part A The application of fluorescence resonance energy transfer to reaction discovery Part B The stereodefined synthesis of tetrasubstituted olefins
… development of methodology for enantioselective reaction monitoring using Fluorescence Resonance Energy Transfer (FRET) is described. The syntheses of enantiomeric epoxides bearing different fluorescent donors and a phenol that bore fluorescence acceptor were explored.* Part B describes the …
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I. Reaction mining—a next-generation platform for reaction discovery II. Rapid, anhydrous, homogenous Suzuki-Miyaura cross-coupling of aryl and alkylboronates
… areas of research and development on: (1) a reaction discovery platform enabled by the merger of high-throughput experimentation (HTE) and data science, and (2) preparative methods for aryl-aryl and B-alkyl Suzuki-Miyaura cross-coupling of boronic esters and boronates. Chapter 1 describes …
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The development of a rhodium-catalyzed chemo- and stereoselective hydroamination for the synthesis of 1,2-diamines
… to a metal center and allow a hydroamination reaction to occur. Hydroamination was seen as a beneficial strategy to synthesize 1,2-diamines as olefins and amines are reacted in an atom-economical fashion. Initial reaction discovery of the rhodium-catalyzed intermolecular hydroamination of …
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Stereospecific Csp3 cross-coupling for modular polyketide synthesis
… alkyl groups using Suzuki-Miyaura cross-coupling reactions. Here, I show that stereospecific palladium-catalyzed cross-coupling reactions of secondary alkyl organoboron nucleophiles can be leveraged to access the alpha-methyl-beta-hydroxyl motif that is ubiquitous amongst polyketide and other …
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Shedding Light on Phytochemical Diversity: Photochromism of chromenes isolated from Piper kelleyi
… products diversity and are likely to inspire new reaction discovery. The following work has resulted in the synthesis of a number of natural products, providing material for their full biological investigation. This material will be used to understand the synergistic action of these …
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Light-Mediated Dual Catalysis for C–N Bond Formation
… of two catalytic species in a single reaction process, has allowed new streamlined and efficient synthetic methods to be developed. This thesis describes efforts towards the development of novel transformations for radical C–N bond formation mediated by photoredox dual catalytic …
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Intermolecular [3+2] Cycloadditions of Imino-isocyanates to Access β-Amino Carbonyl Compounds
… methods for important C-C and C-N bond formation reactions. The challenge lies with establishing new uses for readily available substrates. In this regard, the synthesis of β-aminocarbonyl compounds from alkenes remains a long-standing challenge. Innovation in reaction discovery often requires …
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Development and application of carbon-carbon bond forming methodologies
… tool to the fields of chemical biology and drug discovery. Information gained from introducing unique chemical moieties to biological systems allows for a better understanding of the governing dynamics of cellular mechanisms leading to new treatments for disease. The only way to explore uncharted …
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Diverse Applications of Flow Technology in Discovery Chemistry
… methods and applications of flow technology in discovery chemistry. The first two chapters highlight the use of several beneficial features offered by flow technology to increase the throughput, safety, and convenience of organic synthesis. The last two chapters describe the use of microfluidic …
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The Use of High-Throughput Experimentation to Accelerate the Development of Methods for Complex Amine Synthesis
… methodologies. To continue developing new reactions for the construction of important but increasingly complex molecules, modern chemists need to create faster and more environmentally sustainable methods for reaction discovery. The field of high-throughput experimentation (HTE) is vital to …