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Showing 1 to 8 of 8 for “"Re-replication"”.
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Meiotic Dna Re-Replication And The Recombination Checkpoint
<p>Progression through meiosis occurs through a strict sequence of events, so that one round of DNA replication precedes programmed recombination and two nuclear divisions. Cyclin dependent kinase 1 (Cdk1) is required for meiosis, and any disruption in its activity leads to meiotic defects. The …
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Consequences of partial chromosome re-replication in mammalian cells
To prevent re-replication of DNA in a single cell cycle, the licensing of<br/>replication origins by Mcm2-7 is prevented during S and G2 phases. Metazoans<br/>achieve this by cell cycle regulated proteolysis of the essential licensing factor<br/>Cdt1 and formation of an inhibitory heterohexameric …
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Mechanisms that prevent DNA re-replication in the yeast Saccharomyces cerevisiae
… it must faithfully duplicate its genome before the cell divides. If replication initiates a second time (re-replication) before cytokinesis, cells can accumulate extensive DNA damage, which results in genomic instability, a hallmark of tumorigenesis. To prevent re-replication eukaryotic cells …
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Re-replication in the Absence of Replication Licensing Mechanisms in Drosophila Melanogaster
<p>To ensure genomic integrity, the genome must be accurately duplicated once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate replication once per cell cycle. Disruption of replication licensing …
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Investigation of replication fork progression and re-replication fork instability at the Drosophila follicle cell amplicons
The Drosophila follicle cell amplicons are a well-established model system of origin firing, and have been extensively used to investigate the cis and trans-acting elements that govern origin regulation in metazoan development. Precisely timed origin initiation from defined genomic locations also …
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Mechanisms of genomic stability maintenance in fission yeast
DNA replication consists of two distinct steps: the licensing step during the G1 phase and the initiation step at the G1 to S transition point. During licensing, two inactive complexes of the replicative helicases, MCMs, are loaded onto all the potential origins of replication (ORIs), through the …
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Post-Replicative Resolution of Under-Replication
The evolutionary pressure to prevent re-replication by inactivating licensing during S phase leaves higher-eukaryotes with large genomes, such as human cells, vulnerable to replication stresses. Origins licensed in G1 must be sufficient to complete replication as new origins cannot be licensed in …
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Controls Over S-Phase And Over Nuclear Synchrony
… forty years ago, cell fusion experiments revealed two tenets of our understanding of the cell cycle today. One, controls maintain ordered progression of the cell cycle. Two, diffusible factors in the cytoplasm promote cell cycle transitions. The studies presented here stem from those …