Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Re-activation"”.
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Oedipal dynamics between a male-female co-therapist dyad and a group of adolescent boys with learning difficulties : a case study exploration
Theoretical literature indicates that a male-female co-therapist dyad in a psychotherapy adolescent group provides for the opportunity of parental transferences, including Oedipal conflicts, to occur. However, limited empirical data is available regarding male-female co-facilitation in therapeutic …
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Caught between Islam and the West: secularism in the Kemalist discourse
… discourse as the West and Islam. Kemalism mainly related to the West through the hegemonic discourse of Orientalism, and the Kemalist attitude towards Islam was characterised by its peculiar brand of secularism. Orientalism portrayed the East as irrational in all aspects of the economic, political …
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Re-replication in the Absence of Replication Licensing Mechanisms in Drosophila Melanogaster
<p>To ensure genomic integrity, the genome must be accurately duplicated once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate replication once per cell cycle. Disruption of replication licensing …
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… in the clinic is targeting the androgen receptor and the oestrogen receptor in prostate and breast cancer respectively. Despite the success of these therapies, the mechanisms that maintain lineage fidelity in advanced cancer clones, and whether lineage factor pathways could be exploited …
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Older adults in further education: re-defining careers in a recession, a narrative inquiry.
The focus of this research is an exploration of the impact of the current recession on the older adults’ decision to re-define their career path through further education (FE). I perceived a need for this research as I am concerned that the guidance needs of older professionally qualified, …
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SYSTEMIC AND TRANSGENERATIONAL REGULATION OF GENE EXPRESSION BY SMALL RNAS IN C. ELEGANS
Development of an organism requires information contained minimally within a single cell. This information is inherited in two forms- the genome sequence and regulatory molecules. Little is understood about the types of the regulatory molecules inherited or the impact of parental experiences on …
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The Role of Microglia in the Effects of Steroid Hormones on Brain Inflammation
<p>The conditions defining whether microglial activation is detrimental or beneficial to neuronal survival are still poorly understood. Better understanding of the factors regulating microglia activation may lead to improved therapies for neurodegenerative diseases. Clinical and animal studies …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… However, clinical challenges of toxicity and low response rate offer opportunities to develop novel, rational strategies to integrate into current clinical oncology treatment. To address these challenges, we designed a novel local mesenchymal stromal cell (MSC) based immunotherapy to study the …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
In this dissertation, a careful analysis of different aspects of pancreatic development was conducted in order to expand our understating of the biology of this organ. This thesis encompasses an in depth description of pancreas macro morphology throughout development as well as the analysis of the …
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Regulation of desiccation tolerance in Xerophyta seedlings and leaves
A small, diverse group of angiosperms known as resurrection plants display vegetative desiccation tolerance and can survive loss of up to 95% of cellular water, a feat only seen in the seeds and pollen of other angiosperms. Xerophyta humilis is a resurrection plant native to Southern Africa that …
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Roles of the MicroRNA miR-31 in tumor metastasis and an experimental system for the unbiased discovery of genes relevant for breast cancer metastasis
… miR-31 was identified as a potent inhibitor of breast cancer metastasis. miR-31 expression levels were inversely associated with the propensity to develop metastatic disease in human breast cancer patients. Additionally, various functional analysis revealed that miR-31 expression was both …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular proliferation. pRB binds to the E2F family of transcription factors and …
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Stormy records from peat bogs in south-west Sweden : implications for regional climatic variability and vegetation changes during the past 6500 years
This thesis aims to reconstruct and explain variations in storm activity, humidity, vegetation composition and land cover in south-west Sweden during the past 6500 years. Two ombrotrophic bogs, Store Mosse and Undarsmosse, situated on the coastal plain of Halland, were selected for this purpose. …
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From Face Perception to Individual Recognition: The Missing Link
<p>Recognizing other individuals is a key social aspect of our everyday lives. To recognize a familiar individual, we must establish a link between sensory inputs and a representation of that individual held in memory. In primates, faces play a particularly important role on the sensory side of …
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Design, synthesis, and preliminary biological evaluation of novel small molecules modulating the HuR RNA-binding protein and other therapeutically relevant targets in immuno-oncology.
The International Agency for Research on Cancer (IARC) estimates that 25% of men and 17% of women worldwide develop cancer during their lifetime, making it the second leading cause of death in Europe and America. Many research efforts have been directed against cancer, both from pharmaceutical …
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The electrophysiological and molecular effects of chronic beta-adrenoceptor antagonist therapy on human atrium
The chronic treatment of patients with a β-adrenoceptor antagonist is associated with prolongation of the atrial cell action potential duration (APD), potentially contributing to the ability of these drugs to prevent atrial fibrillation (AF). The mechanisms underlying this APD prolongation are not …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of …
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Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses
… and multi-aetiological process involving suppressions, alterations and re-activation of key biomolecular markers. Some of these changes are recognised by the humoral system and are known as Tumour Associated Antigens (TAA) against which the humoral system is able to mount an auto-antibody …
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Tectonic and climatic control on the evolution of the Himalayan mountain front
… which in turn might affect the state of stress and the level of fault activity. Distinguishing between different forcing mechanisms causing variations of sediment flux and tectonic activity, is therefore one of the most challenging tasks in understanding the spatiotemporal evolution of …