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Showing 1 to 20 of 96 for “"RbcS"”.
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Characterization of apoptotic cell death in bovine red blood cells
Red blood cells (RBCs) in mammalian species display phenotypic variations in cellular functions and metabolism ascribed to their compositional and morphological differences. After accruing stress-induced damages, organelle-free human RBCs display a specialized apoptotic cell death process …
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Exploring the variability in mechanical property testing of dental resin composites
The invention of dental resin based-composites (RBCs) has provided a broad range of materials for the restoration of load-bearing posterior teeth with excellent clinical results and adequate longevity. Currently, a lack of consensus exists among researchers regarding classification of RBCs as a …
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THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION
… lesion refers to changes in red blood cells (RBCs) during storage. It includes a number of chemical and morphological changes in RBCs, which result in reduced integrity of the erythrocyte membrane with formation of microparticles, and increased cell-free hemoglobin in plasma. The geometry of …
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Applying a microfluidic 'deformability cytometry' to measure stiffness of malaria-infected red blood cells at body and febrile temperatures
Red blood cells (RBCs) undergo repeated deformation as they traverse blood vessel, capillaries and splenic cords; RBC deformability is therefore crucial in maintaining normal blood circulation. During falciparum malaria, parasite proteins interact with the spectrin network of host RBCs, moderately …
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Microfluidic devices for analysis of red blood cell mechanical properties
Decreased deformability of human red blood cells (RBCs) is both a cause of disease and biomarker for disease (1). To traverse blood capillaries, the biconcave disk-shaped RBC must deform dramatically, since the diameter of the unconstrained RBC is larger than that of the capillaries. If the RBC …
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EFFECTS OF RED BLOOD CELLS ON NITRIC OXIDE BIOACTIVITY
Red blood cells (RBCs) as one of important cells in human blood vessel are abundant in hemoglobin (Hb). Hb has four heme ferrous sites for binding oxygen, nitric oxide (NO), carbon monoxide (CO) and other small molecules. NO as an endothelial derived relaxing factor is involved in many …
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Physiological and pharmacological factors affecting sickle cell function
… The three most significant abnormal features of RBCs from SCA patients are haemoglobin (HbS) polymerisation, phosphatidylserine (PS) exposure and significantly increased cation permeability via the KCl cotransporter (KCC), and are critical to the pathogenesis of SCD. The outcome of these abnormal …
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A novel approach to real-time monitoring of erythrocyte ATP release as a function of hypoxia
… Recent studies suggest that red blood cells (RBCs) play a role in local vasodilatory signaling by releasing ATP in response to hypoxia. RBC ATP release and overall function are impaired with age and disease. Until now, luciferin/luciferase bioluminescence is the only method described to …
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The Impact of Calcium Binding Protein 5 (CaBP5) on Synaptic Vesicle Dynamics in Rod Bipolar Cells in the Retina
… type 5 ON cone bipolar cells. Rod bipolar cells (RBCs) are essential for rod pathway signaling in the vertebrate retina, and they form ribbon style synapses that enable the continuous transmission of visual information. These synapses rely on SNARE complexes formed between SNAP25, synaptobrevin, …
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Engineered red blood cells and their applications
… a normal adult generates some 2.5 million RBCs, which subsequently circulate through the blood vessels for a lifespan of 50 or 120 days in mouse and human, respectively. RBCs are also unique in that they are completely enucleated once fully mature. These two characteristics exist as …
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Understanding the mechanisms of phosphatidylserine exposure in sickle cells
… leads to a change in red blood cells’ (RBCs) membrane permeability, high phosphatidylserine (PS) exposure, altered RBC rheology and fragility. The high PS exposure is considered to cause some of the hallmark complications of the disease such as vascular occlusion, anaemia and …
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Variability of Cholesterol Accessibility in Human Red Blood Cells Measured Using a Bacterial Cholesterol Binding Toxin
… accessible cholesterol in human red blood cells (RBCs). Accessible cholesterol levels were stable within individuals, but varied >10 fold among individuals. Significant variation was observed among ethnic groups (Blacks>Hispanics>Whites). Variation in accessibility of RBC cholesterol was unrelated …
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The Rational Design and Use of Novel Small-Molecule Ice Recrystallization Inhibitors for the Cryopreservation of Hematopoietic Stem Cells and Red Blood Cells
… (HSCs) and 40% glycerol for red blood cells (RBCs). DMSO fails to protect the functionality of HSCs after cryopreservation and therefore, up to 20% of HSC transplantations fail to engraft. The glycerol in thawed RBC units must be removed to <1% to prevent intravascular hemolysis which is …
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Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX
… where parasites develop within red blood cells (RBCs). Infected RBCs can adhere to the host microvasculature, triggering inflammatory responses in affected organs that contribute to the pathophysiology of life threatening cerebral malaria and pregnancy-associated malaria. The expression of …
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Material Modeling Through Inverse Analysis
… is also introduced to extract Red Blood Cells (RBCs) material stress-strain behavior from measurements of forces and displacements obtained by optical tweezers techniques. Deformation characteristics of RBCs are closely linked to disease (e.g. malaria) progression and hold promise as a tool for …
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IN-VITRO METABOLISM AND PROTEIN BINDING OF 5-HMF, A POTENTIAL ANTISICKLING AGENT
… Moreover, metabolism of 5-HMF in human RBCs was investigated. Finally, in-vitro studies were done to characterize 5-HMF binding kinetics with human Hb and albumin (HSA). Methods. NAD+ reduction was monitored at 340 nm in human hepatic cytosol for 5-HMF (26 mM) and prototypical ADH and …
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Prevention of bacterial growth in platelet products via inclusion of iron chelators
… we hypothesize that residual red blood cells (RBCs) in platelet units may contribute bioavailable iron that promotes bacterial growth. To test these hypotheses, we first assessed growth of Staphylococcus epidermidis in culture medium after treatment with the iron chelators deferoxamine (DFO) or …
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Novel Technologies for Evaluating Red Blood Cell Rheology during Blood Processing and in Sickle Cell Disease
Normal red blood cells (RBCs) are relatively simple in structure as they contain no major organelles and have no nucleus. Because of this, they typically assume a flat biconcave disk shape at low shear rates. This unique shape grants RBCs the flexibility to deform in response to the varying shear …
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The role of small RNAs in C4 photosynthesis
… and transcripts of several genes (most notably RbcS and RCA) were upregulated. These data were complemented by examining the effect of illumination on developing C. gynandra cotyledons, and attempts to generate a hybrid between C. gynandra and the C3 C. hassleriana Chodat. RbcS also showed …
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Regulation of the carbon-concentrating mechanism in Chlamydomonas reinhardtii
… mutants with substituted Rubisco small subunits (RBCS). Low CO2-adapted pyrenoid-less RBCS mutants had impaired growth and low photosynthetic affinity for inorganic carbon (Ci). These pyrenoid-negative strains also showed a specific reduction in the accumulation of several CCM mRNAs, compared to …
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