Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Rb loss"”.
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Role of retinoblastoma protein in the development of liver cancer
… with a diverse aetiology. Dysregulation of the Rb pathway can occur in as high as 92% of liver cancers implicating Rb as an important factor in the progression of the disease. The impact Rb loss has on the development of liver cancer was determined using an in vitro system, with Cre-lox …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular proliferation. pRB binds to the E2F family of transcription factors and …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… we analyze the in vivo roles of three proteins, pRb, E2F4, and p107, in murine embryonic development and in differentiation in vitro. As Rb loss causes embryonic lethality due to placental defects, we adopted a conditional knockout strategy to generate Rb-deficient embryos that survive to birth. …
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Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
… encodes a protein similar to the mammalian pRb tumor suppressor protein. The LIN-35 Rb protein is proposed to act with HDA-1, a histone deacetylase homolog with class B synMuv activity, to remodel chromatin and repress transcription of genes that promote vulval development. To further …