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Showing 1 to 20 of 72 for “"Ratiometric"”.
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A Simultaneous, Split-Beam, Ratiometric System for Spectrochemical Analysis
Made available in DSpace on 2014-12-13T20:09:50Z (GMT). No. of bitstreams: 1 7616116.pdf: 7783009 bytes, checksum: 3fd25773c6a13cfcde5337968ded8e67 (MD5) Previous issue date: 1976
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Establishing Ratiometric Characterisation in Bacillus Subtilis for Biosensing Applications
… has been carried out, and a robust system for ratiometric characterisation has not been established in the bacteria. In this work, a robust platform for rapid ratiometric characterisation is established in B. subtilis. A rigorous mathematical model of the ars operon is developed and analysed …
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A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency
… luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated …
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Ratiometric fluorescent metal ion indicators based on functionalized poly(N -isopropylacrylamide)
<p>A novel type of ratiometric fluorescent indicator based on the phase transition of a well-known stimuli-responsive polymer poly(N-isopropylacrylamide) (PNIPAM) is presented. The sensing mechanism involves the polymer conformational change resulting from charge neutralization by the analyte metal …
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Ratiometric copper(II) indicators based on poly(n-isoproprylacrylamide) and fluorescence resonance energy transfer
<p>An approach to ratiometric fluorescence detection of Cu(II) ions was devised by copolymerizing N-isopropylacrylamide with small percentages of bipyridine and amine monomers. The copolymer was divided into two portions. The amine group on one portion was functionalized with AlexaFluor555 (donor …
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Lanthanide metal-organic framework for ratiometric detection and adsorption of copper ions in water
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01
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Design of a robust ratiometric sensor and a long-term memory genetic toggle switch
… I present a proof-of-concept design for a robust ratiometric sensor, which is a type of multi-input sensor that is especially useful to sense relative biomarker concentrations for in-gut diagnostics. Additionally, I provide design principles for a long-term, yet reversible, memory device, which …
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Design and synthesis of novel functionalized sensors for the biological imaging of zinc(II) and nitric oxide
… to image chelatable zinc(II) in neuronal cells. Ratiometric sensors have been developed for more precise zinc sensing. These sensors exhibit differentiable changes in fluorescence in the presence and absence of zinc. CHAPTER 2. An Esterase-Activated System for the Ratiometric Sensing of …
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Novel Optical Tools to Investigate Presenilin Control of Neurotransmission
… control of ER Ca<sup>2+</sup>, we created a ratiometric version of the low affinity ER-GCaMPs in which we fused the HaloTag protein to allow for direct reporting of ER Ca<sup>2+</sup> levels. We coupled this new indicator with in-cell calibrations at physiological temperatures to create a …
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DUAL-SIGNAL READOUT ANALYTICAL TOOLS: DESIGN, CHARACTERIZATION, AND APPLICATIONS IN SENSING
… It introduces a new generation of bimodal and ratiometric sensors suitable for varied applications, especially in the crucial areas of health and environmental monitoring. The first project details a bimodal sensor designed for the simultaneous detection of cholesterol and o-toluidine, …
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Activatable photoacoustic contrast agents for sensing and delivering nitric oxide, and development of small molecule photoacoustic platforms with improved properties for in vivo imaging
… our group’s work to develop near-infrared, ratiometric photoacoustic probes for nitric oxide, with a focus on my contributions to the synthesis and in vivo studies (Chapter 2), as well as my work toward the synthesis and validation of our near-infrared photoactivatable nitric oxide releasing …
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Fluorinated Metal Complexes as MRI Contrast Agents
… biomarkers of diseased states, lacking a ratiometric mechanism. Fluorine-based MRI does not suffer from these limitations, but its low sensitivity, with a limit of detection (LOD) in the micromolar range first requires a contrast agent designed specifically to address this issue of …
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Molecular engineering strategies for expanding the capabilities of fluorescent zinc (II) sensors
… cells. Chapter 4: Unimolecular Two-Fluorophore Ratiometric Zn²⁺ Sensing Systems. Dichlorofluorescein compounds covalently bound to zinc(II)-insensitive reporter fluorophores via a rigid cyclohexyl linker have been prepared and characterized. Based on favorable photophysical properties, a …
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Resonant cavity Fibre Bragg grating sensor interrogation
… compensation for fluctuating system losses. Ratiometric filter- and diffractive-element spectrometer-based wavelength measurement systems are developed and analysed for different commercial applications. The ratiometric design provides a low-cost solution that has picometre resolution and low …
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Development of enhanced performance luminescence-based optical sensor systems for single-analyte and multii-analyte applications
… and can be used to obtain intensity, phase or ratiometric-intensity measurements. When a luminophore is placed close to a dielectric interface it exhibits an anisotropic emission prole. An optical probe that exploits this phenomenon to achieve enhanced luminescence capture was designed …
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New phosphorescence based probes and techniques for the analysis of cellular oxygen and respiration
… with 2D and 3D cell cultures in intensity, ratiometric and lifetime-based modalities with luminescence readers and FLIM microscopes. Extended range of O2 sensitive probes was designed and studied in order to optimize their spectral characteristics and intracellular targeting, using different …
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Supramolecular quantum dot-porphyrin assemblies for biological oxygen sensing
… as an internal intensity standard, furnishing a ratiometric oxygen sensor. Preliminary in vivo multiphoton imaging and oxygen measurements were conducted using mice with chronic dorsal skinfold chambers or cranial windows. Together, the properties of this sensor establish a ratiometric two-photon …
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Fluorescent Materials for Chemical Sensing
… development and study of a general platform for ratiometric fluorescent chemosensing using surface-immobilized oligomers, as well as in depth explorations of the unique properties of the chemosensors utilizing this platform. It encompasses bichromophoric fluorescent energy transfer cassettes …
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Nanocrystal-molecule energy transfer conjugates for chemical and biological sensing
… 108 s-1 (Chapter II). A reversible and ratiometric NC pH sensor is synthesized by tethering NCs to a squaraine-based pH dye. The presence of an isosbestic point between the two emission maxima from the NC and the dye allows the sensor to be self-calibrating (Chapter III). The ratiometric …
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