Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 459 for “"Rate-limiting"”.
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Investigating the rate-limiting step of mitochondrial complex I catalysis
… proton translocation remains unclear. First, the rate-limiting step of catalysis in complex I was investigated from the point of view of the proton. Using the proteoliposomes system, the pH and solvent isotope dependence of kinetic parameters of purified bovine and *Yarrowia lipolytica* complex I …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
<p>ABSTRACT RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS By Frank Sungping Chen Advisor: Ching-Kang Jason Chen, Ph.D. Retinal photoreceptors provide the first gateway in which light information from the environment is transformed into neuronal signals. The …
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Computational modeling techniques for biological network productivity increases : optimization and rate-limiting reaction detection
… equation (ODE) model based on the mass-action rate law (MRL) of the biochemical reactions. It describes the detailed biochemical mechanisms of the enzyme reactions, and therefore reflects closely of how the enzymes work in the systems. Because the MRL models are constructed with elementary …
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Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… and stress to accentuate the expression of rate-limiting enzymes (indoleamine/tryptophan-2,3-dioxygenase: DOs) that metabolize the essential amino acid tryptophan to kynurenine, 2) detailing a novel interaction between galectins and interferon-gamma to accentuate DO expression within the …
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Kinetic studies of the mechanism of transimination
… and by tertiary amines. Plots of second order rate constants against catalyst concentration are curved, indicating a change in rate limiting step from proton transfer to some other step. The intermediate formed in this sequence is thought to be a geminal-diamine. A Bronsted plot for general …
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Quantitative structure activity relationships of monoamine oxidase catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
… structure act! Vlty relationships of rate s of I-methyl-4-phenyl-l,2,3,6-tetrahydropyridine oxidation catalyzed by monoamine oxidases A and B were performed to elucidate active site substrate conformation and oxidation mechanisms. Plotting experimental kinetic activity against …
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Quantitative analysis and characterization of intracellular gene delivery mechanisms
… may result in unoptimized vectors and potential rate limiting steps unidentified. Quantitative analysis of the gene delivery pathway is essential for the characterization, comparison, and design of vectors. The complex nature of the mechanisms for gene delivery, particularly at the cellular …
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A multiscale model for the oxide ion conducting and proton conducting solid oxide cells
… state theory is used to predict the reaction rate constants for each step based on the free energy barriers, and the continuum theory utilizes the reaction rate constants to obtain the voltage loss-current density relations. We apply the methodology to both the oxide ion-conducting SOCs as …
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Computational Investigations at the Gas-Surface Interface: Organic Surface Oxidation and Hydrolysis of Chemical Warfare Agents and Simulants
… ozone with C60-fullerene and the products of nitrate addition to a vinyl-terminated self-assembled monolayer. In the first system, we followed a reaction pathway beginning with primary ozonide formation through the formation of stable products. Theoretical vibrational spectra were used to …
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Modeling of solid oxide fuel cells
… analyzed all the possibilities of the rate-limiting reaction and proposed rate-limiting switched mechanism. Our model prediction agrees with experimental results significantly better than previous models, especially at high current density.
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Investigating Controls on Variation in Isotopic Fractionation during Biodegradation of Chlorinated Ethenes and Ethanes
… isotope effects occur due to different reaction rates for light and heavy isotope-containing molecules, and are controlled by the bonds broken during degradation. For many primary pollutants, stable carbon, hydrogen, and chlorine isotope effects have been found to fit a Rayleigh model, indicating …
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Selection and optimization of gene targets for the metabolic engineering of E. coli
… Escherichia coli. Three case studies illustrate three disparate approaches to identifying genetic interventions: (i) combining metabolomic measurements with thermodynamic calculations to identify rate-limiting reaction steps in a target pathway; (ii) use of stoichiometric, optimization-based …
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Structure, function, and evolution of proline transport systems in Salmonella typhimurium
Solute transport is an essential and often the rate-limiting step in metabolism and energy utilization. Nutrient uptake across the cytoplasmic membrane is mediated by integral membrane proteins called permeases. The goal of this research was to understand the structure and function of the substrate …
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Lewis Base Catalyzed Enantioselective Aldol Additions: Preparative and Mechanistic Studies
… (KIE) studies have determined aldolization to be rate limiting.
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Computational study on the selectivity of iron-containing hydroxylase
… in the hydroxylation reaction of a model substrate artemisinin catalyzed by three selective P450BM3 variants was studied by combined molecular dynamics (MD) simulations and quantum mechanics/molecular mechanics (QM/MM) calculations. A distinct linear correlation was observed between the …
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Mechanistic studies of magnesium electrodeposition and oxygen reduction for energy storage applications
… in fundamental understandings of important, rate limiting reactions for both batteries and fuel cells. The oxygen reduction reaction can be catalyzed to undergo reduction via two pathways. Oxygen binding energy to the catalyst has previously been shown to determine the activity of the …
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Molecular simulation of crystal growth in alkane and polyethylene melts
… of alkane crystallization, focus has been concentrated on growth rates very near the melting temperature, where the growth of these systems is optically observable. In this temperature range near .., diffusion is not a limiting factor, which has led to theory that models the thermodynamic driving …
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The molecular basis of nucleotide recognition for T7 DNA polymerase
… on several DNA polymerases suggested that a rate-limiting conformational change preceding chemistry accounts for the high specificity following the induced fit mechanism. However, the identity of this rate-limiting conformational change and how it contributes to the fidelity is still under …
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Mechanism of oxygen reduction reaction on transition metal oxide catalysts for high temperature fuel cells
… it has the disadvantage of having to operate at elevated temperatures (>800°C) due to the poor catalytic activity of the oxygen reducing cathode. This thesis research is focused on identifying the fundamental reaction mechanisms and pathways for oxygen reduction reaction (ORR) in …
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Genetic dissection of proline transport by Salmonella typhimurium
Transport is an essential and often rate-limiting step in the growth and metabolism of cells. However, very little is known about the molecular mechanism of substrate transport. Proline transport by Salmonella typhimurium is a good model system for studying the molecular mechanism of ion-driven …
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