Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Rat strains"”.
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Seizure development in kindling fast and kindling slow rat strains
… kindling stimulation in two selectively bred rat strains. In the present study, kindling FAST and kindling SLOW rat strains were shown to exhibit differences in the development and subsequent manifestation of amygdala kindled seizures. SLOW animals required far more stimulations than FAST …
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Characterization of the synergistic effects of cocaine with lateral hypothalamic brain stimulation reward
… food. In the present experiments the curve-shift rate-frequency variant of the brain stimulation reward paradigm was used to characterize the reward-potentiating actions of cocaine in rats lever-pressing for lateral hypothalamic brain stimulation. In Experiment 1 a dose-response curve of cocaine's …
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A study of an animal model of Attention-Deficit/ Hyperactivity Disorder using in vivo chronoamperometry and behavioural responses to methylphenidate and guanfacine
… In this study, the spontaneously hypertensive rat (SHR), the most widely accepted model for ADHD, is compared with the Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rat strains as controls
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… failing hearts of spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. At a physiological stimulation frequency (5 Hz), and temperature (37 °C), the peak stress of SHR trabeculae was significantly reduced compared to WKY, although no differences in the …
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The role of norepinephrine in arousal and attention: a human and rat study
… the LCNE system to enhance the signal-to-noise ratio in stimulus-related neural networks. In addition terminal release of NE from LC neurons responds synergistically with glutamate release from glutamatergic neurons, thereby potentiating its signal. The Yerkes and Dodson (1908) theory of arousal …
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Aging and Sympathetic Neurotransmission in Two Strains of Rats that Differ in Longevity and Immune Profiles
… established. From previous studies in Fischer rats (F344), we have found that during middle age, sympathetic nerve activity (SNA) rises in the spleen followed by a decline in noradrenergic (NA) innervation. Also, increased sympathetic signaling via betaadrenergic receptor (β-AR) and reduced …
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Mitochondrial and chromosomal genomics in type 2 diabetes
… the diabetic GK and the normoglycaemic F344 rats. This reciprocal cross consisted of two individual crosses that shared identical nuclear DNA haplotypes while they differed in the mtDNA haplotypes at 110 nucleotide positions. We performed cross-separated linkage analysis to map QTLs …
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Sympathetic control of carotid body excitability in hypertension: A preclinical study
Previous studies have demonstrated that the integrity of carotid bodies is essential for the development and maintenance of hypertension via exacerbated sympathetic drive. Carotid bodies of spontaneously hypertensive (SH) rats exhibit both hypertonicity and hyperreflexia (i.e., hyper-excitability), …
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Studio degli effetti della pre-esposizione adolescenziale al Δ9-THC nell’autosomministrazione di eroina, in età adulta, in un modello animale di maggiore (ratti Lewis) e minore (ratti Fischer 344) predisposizione all’abuso.
… and addiction resistant Fischer (F344) inbred rat strains represents a useful animal model of different drug vulnerability in light of the different susceptibility to opiates and psychostimulants reinforcing properties. Aim: Thus, the purpose of this study was to investigate the influence of …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
The kininogen-deficient BNK rats were shown to progressively develop salt-sensitive hypertension by accumulation of Na+. It was believed that the kininogen-deficiency is responsible for the defective NaCl excretion leading to a cardiovascular damage. In addition to the kallikrein-kinin system …
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Meccanismo d'azione del Pramipexolo nella terapia della malattia di Parkinson
… associated with its use. Recently, PPX administration has been associated to the development of addictive-like behaviors related to the DA Dysregulation Syndrome, particularly in a subpopulation of treated patients, characterized by impulsive-compulsive personality traits as well as previous …
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Molecular Genetic Analysis of Rodent Non-Insulin Dependent Diabetes Mellitus
… is evidenced by the nearly 100% concordance rate for NIDDM in identical twins. The disease endpoint resolves (in a phenotypic sense) complex interactions of genes and environmental factors affecting glucose transport, production and pancreatic beta cell function. Due to these complexities, …
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Deciphering host-parasite molecular networks mediating resistance to toxoplasma gondii
… and prophylactic agents against T. gondii. Rats, like immunocompetent humans, develop a chronic infection, but vary in their susceptibilities to T. gondii infection depending on the rat strain. Compared to the T. gondii-susceptible Brown Norway (BN) rat, the Lewis (LEW) rat is extremely …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease course of …