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Showing 1 to 1 of 1 for “"Rat perfusion"”.
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Investigations into the Mechanisms that Are Responsible for Reduction in Colonic SN-38 Exposure
… secreted by commensal microbiota, generation of toxic active metabolite SN-38 from irinotecan mediated by intestinal carboxylesterse enzymes in gut and enterohepatic recycling of irinotecan and SN-38, etc., can contribute to the elevation of colonic SN-38 content resulting in severe …