Global ETD Search
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Showing 1 to 2 of 2 for “"Rasa3"”.
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Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism
Rasa3 est une protéine activatrice des small GTPases et fait partie de la famille GAP1 qui cible Ras et Rap1. Bien que l’inactivation catalytique ou la délétion de Rasa3 en souris résulte en de nombreuses hémorragies et à la létalité embryonnaire, la fonction biologique sous-jacente à ces défauts …
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Regulation of LFA-1 on T cells by phosphoinositide signalling
… including the RAP1/RAS GTPase-activating protein RASA3. I found that RASA3 is a critical negative regulator of LFA-1 activation and that RASA3 is inhibited by PI3K signalling. T cells without RASA3 have greatly increased ICAM-1-binding. Mice with conditional deletion of Rasa3 in T cells have …