Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 1 of 1 for “"RasMAPK"”.
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Signalling mechanisms of the tyrosine phosphatase SHP2 upstream of Ras
… its crucial role in the complete activation of RasMAPK in KRas driven cancers. SHP2 is also the most commonly mutated protein in RASopathies such as Noonan syndrome. SHP2 is therefore an important therapeutic target, with allosteric inhibitors ‘locking’ SHP2 in its autoinhibited state currently …