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Showing 1 to 2 of 2 for “"Ras-related C3 botulinum toxin substrate 1"”.
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The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… unknown. Our recent studies revealed that RAC1 (Ras-related C3 botulinum toxin substrate 1), a pleiotropic signaling factor belonging to the Rho family of GTPases, is induced in the uterine stroma during decidualization and angiogenesis, suggesting a role for RAC1 in these critical processes. To …
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A Synthetic Lethal shRNA Screen and Genetic Proof of Concept Identifies RAC1 as a Novel Target to Disrupt Plexiform Neurofibroma Formation
Neurofibromatosis Type 1 (NF1) is a highly penetrant autosomal dominant genetic disorder where mutations in the tumor suppressor gene NF1 leads to decreased neurofibromin. The most debilitating manifestation is the presence of complex multilineage Schwann cell-derived plexiform neurofibromas (PN). …