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Showing 1 to 1 of 1 for “"Ras-proximate-1 (Rap1)"”.
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… of Lyn. We documented the small GTPase Rap1 as a major downstream effector of Lyn to regulate neutrophil adhesion during chemotaxis. Depletion of Lyn abolished chemoattractant-induced Rap1 activation at the cell's leading edge. Furthermore, Lyn controls spatial activation of Rap1 by …