Global ETD Search
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Showing 1 to 20 of 25 for “"Ras signaling"”.
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Uncovering the Complexity of RAS Signaling Networks
… Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity of any …
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Regulation of the Ras Signaling Network in C. Elegans Development
… pattern of cell fates. EGF triggers the LET-60/Ras-LIN-45/Raf-MEK-2/MEK-MPK-1/ERK canonical MAP kinase cascade to induce 1˚ fate and synthesize of DSL ligands for the lateral Notch signal. In turn, LIN-12/Notch induces neighboring cells to become 2˚. In response to lower dose of EGF signal, …
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Regulation of Ras signaling and oncogenesis by plasma membrane microdomains
… (PM) microdomain targeting to the functions of H-Ras and R-Ras. These paralogues have identical effector-binding regions, but variant C-terminal targeting domains (tDs) which are responsible for lateral microdomain distribution: activated H-Ras targets to lipid ordered/disordered (Lo/Ld) domain …
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The role of ras signaling associative learning and memory in Drosophila
Ras is an evolutionally conserved signaling molecule that has been implicated in a variety of cellular events, such as cell proliferation, differentiation, and survival. Recent studies also suggest roles of Ras in neuronal plasticity. I investigated the role of Ras in associative learning and …
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Direct Effects of Metformin On Pi3K and Ras Signaling In Endometrial Cancer
… effect on cell proliferation, PI3K and Ras-MAPK signaling, and apoptosis. A xenograft mouse model was also used to evaluate the effects of metformin treatment on <em>in vivo</em> tumor growth. These preliminary studies demonstrated that K-Ras mutant cell lines exhibited a decreased …
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Identification of altered Ras signaling and intermediate filament hyperphosphorylation in giant axonal neuropathy
… protein. Gal-1 stabilizes the active form of the Ras signaling protein, which functions as a molecular switch to regulate the phosphorylation and subsequent organization of IFs. The connection between these pathways led us to propose that Giga regulates IF phosphorylation and structure by …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… The current study demonstrates that activated Ras enhances the ability of C/EBPa to transactivate the G-CSF receptor promoter and a minimal promoter containing only C/EBP DNA binding sites. Ras signaling activates C/EBPa via the transactivation domain, because it enhances the transactivation …
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Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
… A and class B genes act redundantly to regulate Ras-mediated vulval cell fate specification in the nematode Caenorhabditis elegans. The class B synMuv gene lin-35 encodes a protein similar to the mammalian pRb tumor suppressor protein. The LIN-35 Rb protein is proposed to act with HDA-1, a …
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Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
Activating mutations in RAS oncogenes commonly arise in human cancers. However, in experimental settings, oncogenic RAS has most often been studied at supraphysiological levels of expression. Importantly, work by others showed that the response of murine cells to expression of oncogenic ras from …
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
<p>The Ras family of small GTPases (N-, H-, and K-Ras) is a group of important signaling mediators. Ras is frequently activated in some cancers, while others maintain low level activity to achieve optimal cell growth. In cells with endogenously low levels of active Ras, increasing Ras signaling …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
While hypermorphic Ras mutations are found in approximately 35% of colorectal, 45% of lung and 90% of pancreatic cancers, activated Ras alone is not sufficient to transform normal cells into cancerous tumors. Additional driver mutations or epigenetic alterations are required to cooperate with the …
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Oncogene-driven post-transcriptional regulation in lung cancer
… which alter the activity of proteins in the RAS family, with somatic mutation of the KRAS gene occurring in ~30% of lung adenocarcinoma tumors. A gene of the same family, RIT1, is mutated or amplified in 10-15% of lung adenocarcinomas. Although therapies targeting some KRAS-mutated tumors …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
<p>The Ras family of proteins, composed of H, N, and KRas, function as small GTPases that act as "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras signaling is aberrantly activated in a majority of human cancers either …
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Investigating neurodegenerative diseases with small molecule modulators
… studies of cuspin-1 revealed that increasing Ras signaling upregulates SMN protein abundance via translation, an effect which may be associated with the translational regulator mammalian target of rapamycin (mTOR). These findings suggest that controlled modulation of the Ras signaling pathway …
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Involvement of The Receptor For Advanced Glycation End Products (Rage) In Progression of Pancreatic Cancer
<p>Oncogenic<strong> </strong><em>KRAS</em> is central to several cancer types including pancreatic ductal adenocarcinoma (PDAC), but has been determined to be “undruggable”. Recent studies have indicated that oncogenic <em>KRAS</em> is not constitutively active but relies on a feed-forward …
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Regulation of the localization of Lte1, a S. cerevisiae mitotic exit activator
… Teml, a GTPase that acts at the top of the MEN signaling cascade. The spatial segregation of Lte1 and Teml is particularly important in cells with mispositioned anaphase spindles, and plays a role in the prevention of aneuploidy. A model for the regulation of Lte1 localization across the cell …
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A NOVEL, RAS-INDEPENDENT ROLE FOR NF1 IN MICROTUBULE DYNAMICS AND DAMAGE REPAIR DICTATES SENSITIVITY TO T-DM1 IN HER2 POSITIVE BREAST CANCER.
… protein (GAP) function that attenuates RAS signaling. NF1 encodes Neurofibromin (NF1), a large multifunctional protein consisting of 2,818 amino acids. Because of its large size and difficulty in cloning, NF1 structure has resisted characterization for several years and only recently …
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… we show that homozygous deletion of Nf1, the Ras GTPase gene underlying human neurofibromatosis type 1 syndrome, caused lens dysgenesis in mouse. While early lens specification proceeded normally in Nf1 mutants, lens induction was disrupted due to deficient cell proliferation. Further analysis …
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Structure Based Prediction of Drug-Protein Interactions At Allosteric Sites: to wards Direct Inhibition of The Ras Oncogene
<p>Ras is a monomeric G-protein that mediates multiple signaling pathways. When bound to GTP, Ras binds to and activates effectors and when bound to GDP it does not. Somatic mutations occur in ~15% of all human cancers and cause Ras to be predominantly bound to GTP. Recently, several studies …
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