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Showing 1 to 8 of 8 for “"Ras protein"”.
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Kinetic and Thermodynamic Allostery in the Ras Protein Family
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Cellular Mechanism of Arglabin-Dimethylaminohydrochloride Cytotoxicity
… study was to determine the farnesyltransferase (FTase) inhibitory activity of arglabin-DMA and to investigate the effects of arglabin-DMA on three proteins: Ras, Rho and cyclin kinase inhibitor p21/WAF1/CIP1.</p> <p><em>In vitro</em> FTase assays were used to study the effect of …
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Impact of delta-tocotrienol on human melanoma cell proliferation
… prenylation or dolichylation of growth-related proteins including nuclear Ras, nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, …
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… (FPP), reportedly inhibits farnesyltransferase (FTase) directly by competitively blocking the binding of Ras protein and its posttranslational modification, as suggested in previous studies. But, the mechanisms by which Arglabin-DMA inhibits tumor growth <em>in vivo</em> and <em>in …
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The role and function of the Ras-related protein TC21 in Neurofibromatosis type 1
… 3500 individuals worldwide. Neurofibromin, the protein mutated in NF1 disease, is a GTPase activating protein (GAP) for Ras proteins, inactivating the Ras proteins H-Ras, N-Ras, K-Ras, M-Ras, R-Ras, and TC21. Missense mutations in the GAP related domain of neurofibromin cause NF1 disease, …
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Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen
… Zellen. Eine Transformation von Zellen mit Onkoproteinen wie aktiviertem Ras Protein führt zu einer Steigerung der Expression vom frühen P4 Promotor und zu einer verstärkten Toxizität des Nichtstrukturproteins NS1. Die Verwendung der P4-ns1-P38 Kassette aus H-1 Virus in einem AAV-2 Vektor sollte …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… as growth factors, growth factor receptors, Ras oncoproteins, cytoplasmic protein kinases, transcription factors, anti-apoptotic proteins.<br></br><br></br> In particular, the <i>ras</i> oncogene family includes three members: <i>N-ras, K-ras, H-ras</i>. In non-transformed cells, Ras protein, …
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REDEFINING THE SCOPE OF PRENYLATION: DISCOVERY OF “FORBIDDEN” SUBSTRATE RECOGNITION AND DEVELOPMENT OF METHODS UTILIZING PRENYLATED PROTEINS
… function and cell behavior through changes in protein structure, activity, and localization. Prenylation is one such modification wherein a 15- or 20-carbon isoprenoid group is attached to a cysteine residue near the C-terminus of a substrate protein by one of three enzymes: protein …