Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Ras pathway"”.
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
… Removing a single dose of the EGF receptor or Ras85D suppressed the Ptp69D dominant negative phenotype. Interestingly, the cytoplasmic tyrosine kinase PR2 binds Ptp69D, and the C. elegans homolog of PR2 has been found to suppress the Egfr/Ras pathway. Other evidence suggests that the Egfr/Ras …
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A Role for RAS in V-CRK Transformation
… and EGF receptor (EGFR) stimulation, signalling pathways that might be activated in v-Crk transformed cells were investigated by analogy to pathways utilized by v-Src and the activated EGFR, and a search for serine/threonine kinases activated in v-Crk transformed CEF was conducted. Mapk was …
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Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… CREBBP mutations tends to coassociate with RAS pathway mutations in patients. The approach to study CREBBP mutations' role in leukaemogenesis is to model B-ALL by generating Crebbp and/or KRas mutations in mice. I generated a novel Crebbp LOF mutated long latency, intermediate penetrance …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… genes likely repress the transcription of the Ras pathway ligand lin-3 EGF. Some class B synMuv proteins are homologs of a Nucleosome Remodeling and Deacetylase (NuRD)-like complex and heterochromatin protein 1 (HP1). In addition to a NuRD-like complex, which deacetylates lysine nine of histone …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
<p>The Ras family of proteins, composed of H, N, and KRas, function as small GTPases that act as "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras signaling is aberrantly activated in a majority of human cancers either …
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Elucidating oncogenic mechanisms in human B cell malignancies
… with ALL relapse. Activating mutations in the RAS pathway are common (~50%) and result in hyperactivation of the MAPK pathway. I identified Erk negative feedback control via DUSP6 to be crucial for NRASG12D-mediated pre-B cell transformation and investigated its potential as a therapeutic …
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Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
… as Sox6 and Tcf12, and a novel regulator of the Ras pathway Spred1. RNA-sequencing confirmed the presence of fusion transcripts (transposon mediated effects) for these genes. We demonstrate the clinical relevance of these cooperative genes through comparison with large human glioma databases, …
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The C. elegans class A synthetic multivulva genes inhibit ectopic RAS-mediated vulval development by tightly restricting expression of lin-3 EGF
… of C. elegans redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. The class B synMuv genes encode many proteins known to remodel chromatin and repress transcription. The class A synMuv genes likely also function in transcription, although their specific molecular …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
While hypermorphic Ras mutations are found in approximately 35% of colorectal, 45% of lung and 90% of pancreatic cancers, activated Ras alone is not sufficient to transform normal cells into cancerous tumors. Additional driver mutations or epigenetic alterations are required to cooperate with the …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… 41 kinases and 26 transcription factors. Pathway activity computation and mouse survival curves indicate the NTRK1 mutation induces a higher activation of AKT targets, drives a positive feedback loop to up-regulate multiple other RTKs, and shows higher oncogenic potency than the PDGFRA …
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Studies on the Mechanisms of Malignant Transformation in Neurofibromatosis Type 1
… 신호전달에 관련된 단백질들의 발현 및 수식 양상을 비교분석하는 연구를 실시하였다. Ras activation assay 실험을 통해서 세포내 대표적 Ras pathway regulator인 neurofibromin의 발현량 감소에 의해 활성화 형태의 K-Ras와 H-Ras가 정상표현형 세포에서 악성세포로 갈수록 증가된 것을 확인하였다. 과잉 활성 및 축적된 Ras에 의해 serine/threonine kinase인 ERK의 활성화 형태 phospho-ERK가 증가되었고, 그 downstream 인 …
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Studies on the Molecular Mechanisms of Tumorigenesis in Neurofibromatosis Type 1
… encodes neurofibromin, a tumor suppressor with Ras-GAP activity that negatively regulates p21-RAS signaling. Neurofibromin deficiency typically causes chronic activation of Ras, which is thought to be a major contributor to manifestation of NF1. The cardinal features of NF1 are cafe-au-lait …
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Single Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms
… have identified genetic factors (TP53 and RTK/RAS pathway mutations) and phenotypic factors (monocytic differentiation) to be associated with resistance. In this light, we hypothesized that integrative assessment of genetic and phenotypic factors could further elucidate the unknown mechanisms …
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Identification and characterisation of the Spred protein family
… and they act as negative regulators of the Ras pathway during growth factor stimulation. As the Spred-family members seem to exert similar functions, the specific function of each member remains enigmatic. Therefore, we investigated the mRNA and protein expression patterns of the two murine …
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Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
… of the receptor tyrosine kinase (RTK) signaling pathway. Molecular characterization of spen has revealed that spen encodes a protein with 5476 amino acids. It contains three tandem repeats of an RNA Recognition Motif (RRM) at its N-terminus, suggesting that Spen might function as an RNAbinding …
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Regulation of sphingosine kinase 1 oncogenic signalling by calcium and integrin binding proteins
… associated with oncogenic mutation of KRas. Ectopic expression of oncogenic Ras also led to upregulation of CIB1 expression. In line with a direct role for CIB1 in initiating oncogenesis, I found that overexpression of CIB1 was sufficient to drive the plasma membrane localisation of SK1 …