Global ETD Search
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Showing 1 to 1 of 1 for “"Ras/Raf/Erk-Kaskade"”.
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… SHP2 is also involved in the activation of the Ras/Raf/Erk cascade upon IL-6 stimulation. The C-terminal part of SHP2 is able to recruit the adapter protein Grb2 which links SHP2 to the signal enhancer Gab1. Interestingly, experiments with SHP2 mutants displaying dysregulated phosphatase …