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Showing 1 to 20 of 608 for “"Ras"”.
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Conformational Dynamics of K-Ras and H-Ras Proteins: Is There Functional Specificity At The Catalytic Domain?
<p>Ras proteins serve as crucial signaling modulators in cell proliferation through their ability to hydrolyze GTP and exist in a GTP “on” state and GTP “off” state. There are three different human Ras isoforms: H-ras, N-ras and K-ras (4A and 4B). Although their sequence identity is very high at …
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Uncovering the Complexity of RAS Signaling Networks
… Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity of any …
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Development and Characterization of Novel Ras Inhibitors
<p>Ras genes are mutated in 15% of human cancers. Ras GTPases operate as molecular switches regulating cellular processes including proliferation, differentiation, and apoptosis. The three main isoforms of Ras – H-Ras, K-Ras, and N-Ras – inhabit distinct nanodomains of the plasma membrane and …
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Activation of the c-Ha-ras oncogene
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1984
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Aberrant Ras/MAPK signaling in skeletal development
… (NS), that are caused by aberrant germline Ras/MAPK signaling. One hallmark of these developmental syndromes is a defect in the skeletal development of the patients. However, the in vivo role of MAPK signaling during bone development is still controversial, with some studies supporting a …
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Protein-based Degrader Strategies against Oncogenic RAS
… to cancer cells while preserving healthy cells. RAS proteins play a crucial role in cancer development and are associated with increased tumor growth and invasion. Mutations in RAS genes, especially KRAS G12D, are present in a large proportion of human cancers. However, these proteins have been …
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A Role for RAS in V-CRK Transformation
… which probably mediate activation of the Ras pathway in v-Src transformed and EGF-stimulated cells, were not tyrosine phosphorylated, indicating that the activation of Mapk was probably mediated by a different mechanism. v-Crk transformed NIH-3T3 cell lines were established in order to …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
<p>The Ras family of proteins, composed of H, N, and KRas, function as small GTPases that act as "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras signaling is aberrantly activated in a majority of human cancers either …
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Investigating K-Ras inhibition by α-helical peptides
Mutations in the KRAS gene are common drivers of human cancer and inhibition of KRas is a key goal in drug discovery. Recently, the development of covalent K-Ras(G12C) inhibitors has presented a breakthrough in the field and challenged the belief that K-Ras was "undruggable". Despite this, there …
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WTP for RAS salmon by the US consumer
… method, recirculating aquaculture systems (RAS), which directly addresses the environmental challenges associated with the traditional farming method, open-net pens. Because of the higher costs associated with RAS, the salmon it produces requires a price premium, and little is known about …
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Kinetic and Thermodynamic Allostery in the Ras Protein Family
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Mechanism of mitochondrial respiratory dysfunction by oncogenic K-Ras
… oncogene driving transformation, oncogenic K-RasV12 was adopted to transform cultured fibroblast. When cultured Rat-2 fibroblast cells were infected with a retrovirus harboring constitutively active K-RasV12, the expressions of both respiratory and non-respiratory proteins were decreased. Such …
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Regulation of Ras signaling and oncogenesis by plasma membrane microdomains
… (PM) microdomain targeting to the functions of H-Ras and R-Ras. These paralogues have identical effector-binding regions, but variant C-terminal targeting domains (tDs) which are responsible for lateral microdomain distribution: activated H-Ras targets to lipid ordered/disordered (Lo/Ld) domain …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… (SCCs) are triggered by marked elevation of RAS/MAPK signaling and progression from benign papilloma to invasive malignancy. A subset of tumor-initiating basal progenitors, the cancer stem cells, obtain increased resistance to chemo and immunotherapy along this path. However, the distribution …
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ΜΕΤΑΛΛΑΞΟΓΕΝΕΣΗ ΚΑΙ ΕΝΕΡΓΟΠΟΙΗΣΗ ΤΟΥ RAS ΟΓΚΟΓΟΝΙΔΙΟΥ ΑΠΟ ΑΛΚΥΛΙΩΤΙΚΟΥΣ ΚΑΡΚΙΝΟΓΟΝΟΥΣ ΠΑΡΑΓΟΝΤΕΣ
… INTOTHE CODONS 12 AND 13 OF THE HUMAN HA-RAS1 PROTO-ONCOGENE. THE 06MEG MUTAGENESIS WAS STUDIED IN E. COLI CELLS OF DIFFERENT REPAIR CAPACITIES: 1) O6MEG INDUCEDEXCLUSIVELY G-> A MUTATIONS, 2) THE MECHANISM OF THE METHYL- DIRECTED MISMATCHREPAIR PROTECTS, INDIRECTLY THE E. COLI CELL FROM …
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RAS++: representing hybrid reuse assets for MDE as a service
… a scenario to another one. Thus, we proposed RAS++, a new representation language for hybrid assets. Our research results indicate that RAS++ is representative enough to support implementations of MDE as a Service in evaluated coopetition scenarios.
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Attacking Ras-driven cancers: Engineering a peptide inhibitor for Cdc42
… its downstream effector proteins can reverse Ras-driven oncogenesis. The experiments demonstrating this used the G protein binding region (GBD) of the Cdc42-specific effector ACK, which is 42 amino acids long and binds with 40 nM affinity. The aim of this work was to find a peptide which …
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Signalling mechanisms of the tyrosine phosphatase SHP2 upstream of Ras
… of intracellular signalling pathways, including Ras – mitogen activated protein kinase (MAPK), disrupts normal cell functioning and can lead to various disorders, including cancer and developmental pathologies. SHP2 regulates multiple signalling cascades, including its crucial role in the …
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