Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rare Cancer"”.
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Automatic Tumour Typing based on Patterns of Somatic Passenger Mutations
In cancer, a tumour’s cell of origin is the strongest determinant of its clinical behaviour. While cell of origin is typically clear at the time of diagnosis, 3-5% of cancer patients present with a metastatic tumour and no obvious corresponding primary tumour. Despite advances in molecular testing, …
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Bayesian Integrative Analysis of Omics Data
… and clinical insights into complex diseases like cancer. This dissertation focuses on Bayesian methodology establishment in integrative analysis of radiogenomics and pathway driver detection applied in cancer applications. We initially present Radio-iBAG that utilizes Bayesian approaches in …
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Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse
… is the most common primary liver cancer in infants and young children. Despite being a very rare cancer that accounts for only 0.5-2% if all childhood cancer cases, HB has the largest increase in incidence among childhood cancers in the United States and worldwide. The five-year …
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ALK in the pathogenesis of cancer
… implicated in the pathogenesis of many types of cancer including Anaplastic Large Cell Lymphoma (ALCL) and neuroblastoma (NB). ALK is an ideal drug target as its endogenous expression is limited to neuronal cells during neonatal development, although resistance to ALK-targeted therapy has been …
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Zirconium-based Metal-Organic Frameworks for Pleural Mesothelioma Therapy
… of malignant pleural mesothelioma, an incurable cancer with a survival time of only one year after diagnosis. Mesothelioma is mainly caused by exposure to mining asbestos, a natural fibre widely used in building constructions. This untreatable cancer is histologically classified into three …
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Understanding the supportive care needs of glioma patients and their relatives: a qualitative longitudinal study
Background: Malignant cerebral glioma is a rare cancer but has a devastating impact on patients and their families. In Scotland each year, around 450 people are diagnosed with glioma. Prognosis is generally poor and treatment is essentially palliative. There is a growing recognition that …
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Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry
Vulvar cancer is the fourth most common gynecological cancer around the world, constituting 5% of all gynecological cancers and 0.6% of total cancer cases in 2016. As a relatively rare cancer type, the average vulvar cancer incidence rate is three in 100 000 women each year. But, Australian …