Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Rapid Assembly"”.
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Enantioselective total syntheses of acylfulvene, irofulven, and the agelastatins
… which features metathesis reactions for the rapid assembly of the molecular framework of these anti tumor agents. We discuss (1) the application of an Evans Cu-catalyzed aldol addition reaction using a strained cyclopropyl ketene thioacetal, (2) an efficient enyne ring-closing metathesis …
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Partnering Photochemical Protocols With Anion Relay Chemistry: Application In The Total Synthesis Of Natural Products
… (ARC), a multi-component union tactic, permits rapid assembly of linear and cyclic fragments. Partnering photochemical protocols with Anion Relay Chemistry can provide diverse reaction pathways and as such considerably extends this construction paradigm. The development of new cascade reactions …
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Making Radios with GReasy: GNU Radio With FPGAs Made Easy
Radio technology is rapidly evolving and as processing capabilities and algorithms become more complex, the need for alternative compilation and user interface abstraction increases. Field Programmable Gate Array (FPGA) technology introduces unique reconfigurable hardware architectures that can aid …
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Principles for the design and construction of synthetic circuits utilizing protein-protein interactions in Saccharomyces cerevisiae
… are required. In this thesis, a framework for rapid assembly and delivery of genetic networks in Saccharomyces cerevisiae is described. Utilizing this scheme, design principles of modular chimeric proteins, engineered pathway convergence, and phosphorylated activated localization are developed …
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Studies within Fragment-Based Drug Discovery: Library Synthesis and Hit-to-Lead Optimisation
… which in turn were derivatised to allow the rapid assembly of five (a total of eight in collaboration) spirocyclic scaffolds. Importantly, this library was structurally diverse, comprising three (a total of six in collaboration) pharmacophore-like heterocycles and carbocycles. Moreover, …
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Free4orm framing : high-performance bending-active strip construction
… elastically bent developable strips. Many rapidly-renewable sheet materials exist or are near market, and the local availability of flatbed machining increases with each new makerspace. Thus, this thesis proposes using simple cutting and bending operations, site-applied attachments, and …
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Modularity of the MIT Pebble Bed Reactor for use by the commercial power industry
… the improved quality in the factory setting, and rapid assembly at the site that the total time and cost of construction of the plant will be greatly reduced (Kadak). To make this process work, it is vitally important to assure that when the space frames and internal components are manufactured, …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… Our modular approach has the potential to allow rapid assembly of liver constructs with clinically significant cell densities, uniform cell distribution, and endothelialized, perfusable channels.</p>
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Phosphate Tethers in Synthesis: The Total Synthesis of Dolabelide C.
… and complex olefin partners allowed for rapid assembly of advanced polyol subunits. Understanding the reactivity of the bicyclic phosphate allowed for the application of this methodology toward the synthesis of a natural product. The target chosen was dolabelide C, a 24-membered …
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Synthetic Auxin Engineering: Building a Biofoundry Platform
… Next, I describe and validate a platform called AssemblyTron, which deploys liquid handling robotics for DNA assembly and can serve as the foundation of a biofoundry platform. I then introduce TidyTron, which is a protocol library for automated wash and reuse of single use lab plastics to promote …
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The Development of Vinylheteroarene Linkers for Proteinogenic Cysteine Modification and Studies Towards Applying (+)-Discodermolide as a Novel Payload in Antibody-Drug Conjugates
… step, making this a promising approach for the rapid assembly of ADCs using unexplored alcohol cytotoxins. Using this linker, a discodermolide ADC was successfully synthesised which can be used for biological evaluation.
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Visible-light-mediated synthetic strategies for the synthesis of α-tertiary amine derivatives
… a need to develop synthetic methodologies which rapidly deliver materials containing the α-tertiary amine motif. This thesis describes the development of two distinct, multicomponent approaches for the rapid assembly of these important materials from relatively simple precursors; both methods are …