Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Rapamycin complex 2 (mTORC2)"”.
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… for Rictor, a component of Mammalian Target of Rapamycin Complex 2 (mTORC2), in regulating assembly of the actin cytoskeleton during neutrophil chemotaxis. Depletion of Mammalian Target of Rapamycin (mTOR) and Rictor, but not Raptor, impairs actin polymerization, leading edge establishment and …
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The Regulation of Mtorc2 Kinase Activity and Complex Integrity
… Recently, the</p> <p>mammalian Target of Rapamycin Complex 2 (mTORC2) was identified as the</p> <p>main Akt Ser-473 kinase, and Ser-473 phosphorylation is required for Akt</p> <p>hyperactivation. However, the detailed mechanism of mTORC2 regulation in</p> <p>response to growth factor …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… of Rap1 by recruiting the CrkL/C3G protein complex to the leading edge. Together, these results provide novel mechanistic insights into the poorly understood signaling network that controls leading edge adhesion during neutrophil chemotaxis. In my second research project, we have explored …