NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 214 for “"Rapamycin"”.

  1. The biosynthesis of rapamycin

    Khaw, Lake EeUniversity of Cambridge1995

    cambridge Repository record

  2. Biosynthesis of rapamycin by streptomyces hygroscopicus

    Paiva, Nancy L. (Nancy Louise)Massachusetts Institute of Technology1988

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1988.

    mit Repository record

  3. The Generation of Novel Fluorinated Rapamycin Analogues

    Lanceron, SimonUniversity of East Anglia2010

    east-anglia Repository record

  4. Studies towards the total synthesis of rapamycin

    Willis, Michael CharlesUniversity of Cambridge1995

    cambridge Repository record

  5. Synthetic studies on the C10-C17 fragment of rapamycin

    Norman, JoanneUniversity of Cambridge1994

    cambridge Repository record

  6. Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae

    Pracheil, Tammy

    <p>An integrative, biochemical, genetic, and molecular biology approach utilizing gene manipulation, gene knock outs, plasmid based protein expression, and <em>in vivo</em> protein localization of fluorescence tagged proteins was employed to determine the function of an essential protein, Lst8, in …

    uno Repository record

  7. Regulation of Skeletal Muscle Differentiation by a Rapamycin -Sensitive Signaling Pathway

    Erbay, EbruUniversity of Illinois at Urbana-Champaign2015

    … is completely dispensable. Both the FKBP 12-rapamycin binding domain (FRB) and the kinase domain are necessary for mTOR's myogenic function despite kinase activity being dispensable. These observations provide structural insights into the regulatory mechanisms of mTOR, possibly involving …

    uiuc Repository record

  8. Identification of a new tumor suppressor pathway modulating rapamycin sensitivity in colorectal cancer

    TAN JING2011

    … Small molecule drugs targeting mTOR, such as rapamycin, have been shown to be promising for cancer therapy. However, the clinical responses to the rapamycin as mTOR-targeted therapy are frequently confounded by acquired resistance. In colon cancer, loss of PPP2R2B leads to induction of …

    nus Repository record

  9. The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes

    Hukelmann, Jens LudgerUniversity of Dundee2014

    The serine-threonine kinase mammalian target of rapamycin (mTOR) is an important integrator of nutrient, cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is …

    dundee Repository record

  10. Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin

    Bachmann, Rebecca AnneUniversity of Illinois at Urbana-Champaign2015

    Unexpectedly, mTOR has been found to shuttle between the nucleus and the cytoplasm, and this shuttling is required for its cytoplasmic signaling. I have further investigated the regulation and function of mTOR cytoplasmic-nuclear shuttling. A systematic screen of mTOR revealed a rev-like NES …

    uiuc Repository record

  11. The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis

    Minton, Dennis MichaelUniversity of Illinois at Urbana-Champaign2020

    … Inhibiting the mechanistic target of rapamycin (mTOR) and stimulating AMP-activated protein kinase (AMPK) has extended lifespan and protected against post-traumatic (secondary) OA in mice. However, it remains unknown if manipulation of these pathways can protect against naturally …

    uiuc Repository record

  12. Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury

    Desai, Shivani Kirit2014

    … by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits protein synthesis through inhibition of the mammalian target ofrapamycin (mTOR). This property of rapamycin …

    vcu Repository record

  13. The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease

    Sengupta, ShomitMassachusetts Institute of Technology2010

    … We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body postnatal growth similar to reduced caloric intake. We found that while feeding activated mTORC 1 in almost every tissue, there was variability in the upstream activating stimuli. The role of mTORCl in organ …

    mit Repository record

  14. Role of PRAS40 in mammalian target of rapamycin (mTOR) modulation in cancer and insulin resistance

    Malla, Ritu2018

    <p>Dysregulation of PI3K-AKT-mTOR pathway has been reported in various pathologies, such as cancer and insulin resistance. The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR …

    u-pacific Repository record

  15. Effects of rapamycin and insulin on the cell cycle and apoptosis of hybridoma cell cultures

    Balcarcel, R. RobertMassachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.

    mit Repository record

  16. The effect of mTOR inhibitor rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis

    Pignanelli, Michael TThe University of Western Ontario2020

    … The mechanistic (mammalian) target of rapamycin (mTOR) activity is characteristic of metabolic syndrome. When nutrients are abundant, mTOR is active. Conversely, fasting inhibits mTOR. Metabolic syndrome is correlated with an increased risk of self-reported or imaging findings of …

    uwo Repository record

  17. Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms

    Workman, Jason J.2016

    … signaling complexes, such as the target of rapamycin complex 1 (TORC1), to downstream chromatin modifying enzymes. These enzymes impact the gene regulatory process through altered histone post-translation modifications, changes in chromatin structure, and docking of chromatin regulatory …

    tenn-hsc Repository record

  18. Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes

    Rahman, Hazir2012

    The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In humans, mTOR deregulation is implicated in parasitic, fungal, bacterial and viral infections, immune disorders, …

    goettingen Repository record

  19. The Effect of Rapamycin Paired with Traumatic Memory Activation on Cognitive Performance in Veterans Diagnosed with PTSD

    Anderson, Elizabeth Hallen2012

    … symptoms. Animal studies have shown that rapamycin, a protein synthesis inhibitor that targets the protein kinase mTOR, can prevent the reconsolidation of a reactivated fear memory, thereby reducing its emotional strength at a neurochemical level. The aim of the current study was to …

    utswmed Repository record

  20. Investigation into the effects and mechanisms of rapamycin treatment in two mouse models of Complex I-deficient neurological pathology

    Yanos, Melana2014

    … that inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway is effective at reducing markers of pathology in experimental models of age-related and developmental neurological diseases. These include, but are not limited to, models for Alzheimer's disease, Parkinson's …

    washington Repository record

Page 1 of 11