Global ETD Search
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Showing 1 to 2 of 2 for “"Rap1A/1B"”.
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… through cAMP and the downstream effectors EPAC1, Rap1A/1B, and ERK1/2. Activation of GPR68 under acidic conditions also shows possible influence on intracellular calcium and the cytokine IL-6. In comparison, our in vivo arterial injury studies that mimic acidic vascular conditions suggest a …
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G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
… reduced Gs signaling via the cAMP targets Rap1A/1B and ERK1/2 under acidotic and hypoxic conditions, whereas no changes were observed in GPR68 KO cells in acidic versus normal conditions. Following treatment under ischemia/hypoxia conditions, b-arrestin appears to be upregulated compared to …