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Showing 1 to 15 of 15 for “"Raloxifene"”.
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IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES
Tamoxifene (TAM) e raloxifene (RAL) sono modulatori selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno …
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Thermoneutral Housing Did Not Impact the Combined Effects of External Loading and Raloxifene on Bone Morphology and Mechanical Properties in Growing Female Mice
Raloxifene is an FDA-approved selective estrogen receptor modulator (SERM) that improves tissue quality by binding to collagen and increasing the bound water content in the bone matrix in a cell-independent manner. In this thesis, active tissue formation was induced by non-invasive external tibial …
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Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels
… replacement therapy (HRT), alendronate, and raloxifene. Methods. A hypothetical cohort of white women aged 45--85 years, postmenopausal, and without past incidence of osteoporotic fractures was treated with one of the three alternatives, and tracked over 3 years in a decision model. The CE …
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Interplay Between Estrogen Response Element Sequences and Ligands Controls Binding of Estrogen Receptor to Regulated Genes
… the pure antiestrogen ICI 182,780 nor the SERM Raloxifene activates either PI-9 or pS2. Surprisingly, ICI-liganded ER behaves more like OHT-liganded ER on PI-9 and pS2, while Raloxifene-liganded ER behaves more like Moxestrol-liganded ER. Based on these combined data, I propose that the …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… (P<sub>4</sub>), or with the clinical compounds, raloxifene and asoprosnil in the presence and absence of the MAPK inhibitor, PD98059. The tissue studies showed that tumors taken from the proliferative phase expressed significantly higher levels of ERα-phospho-Ser118, phospho-p44/42 MAPK, and PCNA …
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Estrogen Receptor -Dependent and Estrogen Receptor-Independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-Induced Programmed Cell Death
… an ER-dependent pathway. 17beta-estradiol, raloxifene, and ICI 182,780 are all effective competitors, which block OHT-ER and Tam-ER-dependent cell death. Since the p38-specific inhibitor SB203580 blocks OHT-ER induced cell death, stress kinase pathways are likely involved. ER-independent …
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Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… agents (Tamoxifen, 4-Hydroxytamoxifen OHT, Raloxifene, Anastrozole) to select viable strains for resistance studies. MCF7 (luminal-type A) and MDA-MB-231 (triple negative breast cancer, TNBC) were selected and initially subject to OHT or raloxifene exposure with gradual increments for 10 …
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Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer
… cells treated with 17b-estradiol (E2), raloxifene and tamoxifen, indicating a potentialrole for TTC5 in breast cancer progression and survival. Effects of TTC5 silencing oncyclin D1 makes this molecule a candidate for inhibiting cyclin D1 gene expression. In summary, this thesis uncovers …
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Regulation of osteoblast activity by Pyk2-targeted approaches
… than WT OBs. In the presence of E2 or raloxifene, a selective estrogen receptor (ER) modulator, both matrix formation and mineralization were further increased in Pyk2-KO OBs, but not WT OBs. Consistent with a role of Pyk2 in E2 signaling, Pyk2-depletion led to the proteasome-mediated …
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Estrogen Receptor Ligands and Regulation of Gene Expression
… receptor modulators (SERMs) tamoxifen and raloxifene. KRT13 is a cytoskeleton protein while CALCR mediates the biological effects of calcitonin. These two genes may play important roles in breast cancer growth and metastasis. Analysis of the promoters and regulatory regions of these two …
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Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells
… these assays into human islets revealed that raloxifene treatment results in a significant increase in insulin mRNA expression as well as differentially regulating genes that may be involved in β-cell health. In addition to testing isoforms and variants, coregulator interaction with the …
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Structural Basis for the Molecular Recognition of Androgen Receptor Ligands: Insights Guiding the Design and Synthesis of Novel Nonsteroidal Ligands
… or the estrogen receptor LBD bound to raloxifene, respectively. The initial homology-modeled LBDs were refined using the new approach of multiple molecular dynamics simulations (MMDS). Key H-bonding partners with the 17-hydroxy group and 3-keto group of testosterone are Asn705 and …
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Identification and characterization of estrogen receptor-regulated gene expression programs
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-15T10:00:18Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Cell and Developmental Biology (ID: 702) No. of bitstreams: 4 Barnett_Daniel.pdf: 1415172 bytes, checksum: …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… in other antiestrogens including fulvestrant, raloxifene, bazedoxifene, idoxifene and lasofoxifene (Chapter 7).</p>
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Kurzzeiteffekte von Estradiol, Raloxifen, Phytohormonen und Parathormon auf die metaphysäre Frakturheilung des manifest osteoporotischen Knochens der Ratte
Osteoporose ist nach Einstufung der WHO eine der zehn gravierendsten Volkskrankheiten mit weltweit ca. 200 Millionen betroffenen Menschen. Zentrales Problem dieser systemischen Skeletterkrankung, die zu verminderter Knochenmineraldichte und einer gestörten Mikroarchitektur führt, ist die Fraktur …