Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"RalB"”.
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UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS
… two highly similar small GTPases, RalA and RalB. They are the two members of the Ras-like (Ral) GTPases in the Ras subfamily. Despite their similar biochemical and structurally properties, the Ral GTPases can exhibit diverging roles. My thesis work provides important insights into the …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… of Ral that are downstream of RalGDS (RalA, RalB) and whose actions are mediated by the exocyst. In these experiments, mTOR inhibition was maintained in response to starvation and Torin 1 despite RalA or RalB knockdown; however, autophagy was diminished only in NRCM's with RalB knockdown, …
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Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation
Ral (RAS-Like) GTPases, RalA and RalB, were originally identified based on sequence similarity to Ras and are directly activated via the Ras effector family Ral guanine nucleotide exchange factors (RalGEFs). Previous studies have demonstrated that RalA and RalB collaborate to maintain …
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Investigating the C-terminal region of RalA: regulation through membrane dynamics and protein-protein interactions
RalA and RalB, members of the Ras superfamily, play a pivotal role in tumour progression in Ras-driven cancers, hence there is a growing need to understand these proteins in terms of their structure and function to facilitate future pharmaceutical intervention in this critical oncogenic pathway. So …
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Development of stapled peptides targeting the Ral GTPases
… evidence implicating the Ral GTPases, RalA and RalB, which are activated downstream of Ras, as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. Therefore, targeting this pathway may provide an effective method for inhibition of oncogenic Ras signalling. Prior work …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
… activate two other small GTPases, RalA and RalB. The role of these two proteins in Ras-mediated cancer was poorly understood. I thus assessed the requirement of RalA and RalB in tumor metastasis discovering that both proteins promote this critical step in cancer.</p><p>Ras does not, however, …