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Showing 1 to 20 of 217 for “"Ral"”.

  1. Development of stapled peptides targeting the Ral GTPases

    Hurd, CatherineUniversity of Cambridge2020

    … has been substantial evidence implicating the Ral GTPases, RalA and RalB, which are activated downstream of Ras, as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. Therefore, targeting this pathway may provide an effective method for inhibition of oncogenic Ras …

    cambridge Repository record

  2. Cloning and characterization of RIP1, an effector of Ral

    Park, Sang-HoMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  3. Ral-GTPases as calmodulin binding proteins in signal transduction pathways

    Clough, Richard Royden2004

    manitoba Repository record

  4. UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS

    Spiegelman, Nicole AlexisCornell University2018

    … understanding two highly similar small GTPases, RalA and RalB. They are the two members of the Ras-like (Ral) GTPases in the Ras subfamily. Despite their similar biochemical and structurally properties, the Ral GTPases can exhibit diverging roles. My thesis work provides important insights into …

    cornell Repository record

  5. The development of the notion of libraries in the ancient world with special reference to the Middle East, the Roman Republic and the Royal Alexandrian Library

    Ruppelt, NielsLibrary and Information Studies Centre (LISC)1993

    The Royal Alexandrian Library (RAL) is considered by modern scholarship to represent the epitome of the development of ancient librarianship. Its extensive holdings imply the application of modern organizational procedures such as collection development, information retrieval and promotion of use - …

    cape-town Repository record

  6. Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation

    Cheng, Tzuling2010

    Ral (RAS-Like) GTPases, RalA and RalB, were originally identified based on sequence similarity to Ras and are directly activated via the Ras effector family Ral guanine nucleotide exchange factors (RalGEFs). Previous studies have demonstrated that RalA and RalB collaborate to maintain …

    utswmed Repository record

  7. Regulation of the Ras Signaling Network in C. Elegans Development

    Shin, HannaTexas A & M University2018

    … fate and synthesize of DSL ligands for the lateral Notch signal. In turn, LIN-12/Notch induces neighboring cells to become 2˚. In response to lower dose of EGF signal, LET-60/Ras switches effectors to use the RGL-1/RalGEF-RAL-1/Ral modulatory signaling cascade to promote 2˚ fate in support of …

    tamu Repository record

  8. IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES

    SFOGLIARINI, CHIARAUniversità degli Studi di Milano2026

    Tamoxifene (TAM) e raloxifene (RAL) sono modulatori selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno …

    milano Repository record

  9. Synthesis of Heteroleptic Redox-active and Spin-crossover Complexes

    Pelaccia, MarkBrock University2020

    … mixed ligand complexes in the form of [(Qsal)Fe(RAL)]+X- and [(Qsal)Co(RAL)]+X- have been realized from the use of mononuclear [(Qsal)FeCl2(CH3OH)] and [(Qsal)Co(OAc)]+OAc- species, respectively. The redox-active ligand (RAL) component is an arylazo ligand like 10-(8-quinolylazo)-9-phenanthrol …

    brock Repository record

  10. The disordered N-terminus of RLIP76: a hub for protein and membrane interactions

    Cornish, JasmineUniversity of Cambridge2021

    RLIP76 is an effector for the Ral family of small GTPases. Ral proteins are themselves downstream of Ras, and Ras mutations drive around 20% of all cancers. RLIP76 has been implicated in a number of cell processes ranging from receptor mediated endocytosis, to mitochondrial fission and metabolite …

    cambridge Repository record

  11. The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand

    Zidane, Bassam N2019

    … the development of combined antiretroviral therapy (cART) regimens has decreased mortality and significantly improved the overall quality of life for these patients. However, approximately half of all patients clinically manifest with HIV-associated neurocognitive disorder (HAND), a …

    penn Repository record

  12. Pengaruh pemberian ekstrak biji jintan hitam (Nigella sativa Linn.) terhadap kadar asam urat darah dan gambaran histologi ginjal mencit (Mus musculus) hiperurisemia

    Hayah, Rimah karimatulUniversitas Islam Negeri Maulana Malik Ibrahim2010

    … ini menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan yang diberikan adalah ekstrak biji jintan hitam dengan dosis 1,3 mg, 2,6 mg dan 3,9mg/ ekor/ hari selama 30 hari kemudian diukur kadar asam urat darah dan dilihat gambaran histologi glumerolus …

    malang Repository record

  13. Diseño y caracterización de inhibidores de la fascina para el bloqueo de la invasión y la metástasis en cáncer colorrectal.

    Alburquerque González, Begoña2022

    … en una diana para el bloqueo de la invasión tumoral. Objetivos: El principal objetivo de de la presente Tesis ha sido buscar nuevos inhibidores contra la fascina en cáncer colorrectal mediante cribado farmacológico. Posteriormente, hemos evaluado, mediante técnicas in vitro, el efecto de estos …

    murcia-diss Repository record

  14. RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy

    Rifki, Oktay Feridun2016

    … cultured neonatal cardiomyocytes two isoforms of Ral that are downstream of RalGDS (RalA, RalB) and whose actions are mediated by the exocyst. In these experiments, mTOR inhibition was maintained in response to starvation and Torin 1 despite RalA or RalB knockdown; however, autophagy was …

    utswmed Repository record

  15. Numerical Simulation of Natural Convection in Rectangular Enclosures of Varying Aspect Ratios and its Feasibility in Environmental Impact Management Studies

    Walker, Charles R.2014

    … Numerical simulation was used to investigate natural convection in horizontal and vertical enclosures with and without an internal heat source. Natural convection in rectangular enclosures is found in many real-world applications. Included in these applications are the energy efficient design of …

    gsu Repository record

  16. Pengaruh konsentrasi sari buah pepaya (Carica papaya) dan lama pemeraman terhadap kualitas dan kuantitas minyak kelapa (Cocos nucifera var. Viridis)

    Ramadhani, Fitri AuliaUniversitas Islam Negeri Maulana Malik Ibrahim2010

    … yang digunakan adalah rancangan acak lengkap (RAL) faktorial. Penggunaan metode RAL faktorial mempunyai dua faktor yaitu, faktor pertama (F1) adalah konsentrasi sari buah pepaya dengan 4 level yaitu 3,61 % (15 ml), 4,76% (20 ml), 5,88% (25 ml), dan 6,98% (30 ml). Faktor kedua (F2) adalah lama …

    malang Repository record

  17. Distribusi peletekan telur hama kepik coklat Riptortus linearis (L.)(Hemiptera: Alydidae) pada kedelai

    Laila, Lia FatraUniversitas Islam Negeri Maulana Malik Ibrahim2010

    … disusun menggunakan rancangan cak lengkap RAL) Faktorial. Faktor pertama adalah tanaman kedelai tanpa gulma dan tanaman kedelai yang ada gulmanya, sedangkan faktor kedua adalah umur tanaman kedelai meliputi, 35 hari setelah tanam (HST), 42 (HST), 49 (HST),56 (HST), dan 63 (HST). Hasil …

    malang Repository record

  18. Pengaruh Pemberian variasi konsentrasi konsorsium starter bakteri dan susu skim terhadap kualitas yoghurt susu kacang hijau (Phaseolus radiatus)

    Inarwati, InarwatiUniversitas Islam Negeri Maulana Malik Ibrahim2013

    … ini menggunakan Rancangan Acak Lengkap (RAL) dengan 2 faktor. Faktor pertama pemberian variasi konsentrasi konsorsium starter bakteri 6%, 8%, 10%; faktor kedua pemberian variasi konsentrasi susu skim 0%, 7%,9%, 11%. Parameter yang diamati sifat kimia (kadar asam laktat, kadar protein, …

    malang Repository record

  19. Pengaruh ektrak daun pegagan (Centella asiatica) terhadap spermatogenesis mencit (Mus musculus)

    Hasanah, Ifnaini WirdatulUniversitas Islam Negeri Maulana Malik Ibrahim2009

    … dengan menggunakan Rancangan Acak Lengkap (RAL) dengan 6 ulangan. Perlakuan yang digunakan adalah mencit sebagai kontrol, mencit yang diberi ekstrak daun pegagan dengan dosis 75, 100 dan 125 mg/kg bb. Penelitian ini dilakukan di laboratorium Bisistematik Jurusan Biologi Fakultas Sains dan …

    malang Repository record

  20. Aplikasi pupuk hayati berbahan baku mikroba endofit yang berpotensi dalam meningkatkan pertumbuhan dan ketahanan tanaman kentang terhadap serangan nematoda sista kuning (Globodera rostochiensis).

    Sunaria, Mega Gigih Septiana IisUniversitas Islam Negeri Maulana Malik Ibrahim2011

    … dengan menggunakan rancangan acak kelompok (RAL) tunggal. Penelitian ini dilaksanakan pada bulan Juni sampai dengan September 2010, di laboratorium mikrobiologi Unversitas Islam Negeri Maulana Malik Ibrahim Malang, tanaman kentang ditanam di green house desa Sumber Brantas Kab. Batu, …

    malang Repository record

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