Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Raf1"”.
-
Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium
… In this study, MAP kinase, S6 kinase, p74 [raf1 superscript] and casein kinase-2 (CK-2) were characterized by chromatographic and immunoblotting techniques using both control and diabetic rats. The effects of insulin-mimetic vanadium compounds on these kinases were also examined. Intravenous …
-
Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… of BAD (BAD), HER2 (ERBB2), IGF1R (IGF1R), RAF (RAF1), and KRAS (G12V), using the Bioconductor package, Adaptive Signature Selection and InteGratioN (ASSIGN). Gene lists of various lengths were generated ranging from 5 to 500 genes produced in 25 gene increments. Pathway activation estimates were …
-
USING CHEMICAL AND PROTEOMICS APPROACHES TO STUDY THE FUNCTIONS OF SIRT6 AND KRAS
… I found that KRas4a interacts more with Raf1 than KRas4b does, which may contribute to the more anchorage-independent colony formation in KRas4a transformed NIH 3T3 cells than in KRas4b transformed NIH 3T3 cells. Moreover, mTOR was identified as a KRas4a/b interaction protein. Different …
-
Genetic investigation of South Africans with the Noonan Syndrome phenotype using targeted next generation sequencing
… CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, SOS1 and SPRED1. Results: Of the 26 patients included, 50% had a family history suggestive of NS. The median age at diagnosis was4.5 years (range: 1month-51years). Individuals of mixed-race ancestry were most represented (53.8%), …
-
Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
The RAS-regulated RAF-MEK-ERK1/2 signalling pathway is critical for transducing extracellular signals from receptor tyrosine kinases at the plasma membrane through to protein targets to direct cell fate. Components of this pathway are frequently mutated to drive enhanced signalling in cancer and a …
-
Optogenetic control of developmental signaling pathways
How a complex multicellular organism forms from a single cell is a question that defies simplistic understanding. Yet, embryonic developmental programs use a surprisingly small set of signaling pathways to pattern the embryonic tissue into germ layers from which the various tissues and organs …