Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Raf-Kinase"”.
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or activation. The mitogen activated-protein kinase (MAPK) pathway is known to be downstream from integrins and regulate survival, …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… process in a manner that depends on protein kinase C (PKC)-mediated signaling. We identify PKC[epsilon] and PKC[zeta] as regulators of EC lumenogenesis in 3D collagen matrices. We further show that Src family kinases (SFKs) are involved in this PKC [epsilon]-mediated EC lumen formation …
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
The RAF/MEK/MAP Kinase signal transduction cascade is the most extensively studied MAPK pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. The Ras effector and E3 ligase family member IMP (Impedes …
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Protein kinases that phosphorylate 14-3-3 isoforms
… of S233 by the serine /threonine protein kinase Casein kinase la (CK1 a) was shown to negatively affect the interaction with Raf kinase. The group of Gotoh have recently shown that phosphorylation of S185 by the stress activated kinase c -Jun NH2- terminal kinase (JNK) negatively effects …
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
The RAS-regulated RAF-MEK-ERK1/2 signalling pathway is critical for transducing extracellular signals from receptor tyrosine kinases at the plasma membrane through to protein targets to direct cell fate. Components of this pathway are frequently mutated to drive enhanced signalling in cancer and a …
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Uncovering the Complexity of RAS Signaling Networks
The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity …
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The Role of The Diras Family Members In Regulating Ras Function, Cancer Growth and Autophagy
… cluster formation inhibiting the activation of Raf kinase, which is dependent upon membrane localization and the N-terminal extension. This observation provides a novel approach to target oncogenic Ras and assesses the functional significance of Ras clustering/multimerization.</p> <p>The …
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Role of Raf family members in mouse development
Raf Proteine sind Serin/Threonin Kinasen, die als zentrale Elemente des Ras, Raf, Mek, Map Kinase Wegs, an der Weiterleitung von extrazellulären Signalen von der Zellmembran zu nukleären Effektoren beteiligt sind. Auf diese Weise kontrollieren sie elementare Prozesse wie Proliferation, …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, the Raf protein family of …
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Biomarker development for gastrointestinal and ovarian cancer: a proteomic approach
… response in gastrointestinal and ovarian cancer. Raf Kinase Inhibitor Protein (RKIP) was originally purified from bovine brain extracts and named phosphatidylethanolamine-binding protein (PEBP). It has subsequently been shown to be a widely expressed and highly conserved protein. Several recent …