Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Raf-1."”.
-
RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation
Raf-1 kinase inhibitor protein (RKIP) is initially known as a suppressor for Raf-1-mediated ERK activation. Moreover, recent findings indicate that RKIP also has a role in G-protein-coupled receptor (GPCR) desensitization. Protein kinase C (PKC)-mediated phosphorylation at Serine 153 (S153) on RKIP …
-
The Role of Raf-mediated Signalling Pathways for Motoneuron
… of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, the Raf protein family of …
-
The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
… indicating that cAMP can switch on the Rap1/B-Raf pathway. This correlated with the increase in the phosphorylation of ERK in response to high levels of cAMP upon EGF stimulation. Then, the role of Raf-1 and C3G, a guanine exchange factor for Rap1, were investigated using small interfering RNA. …
-
Identification of novel biomarkers for clinical prognosis in breast cancer
… of kinases and transcription factors e.g. c-RAF-1, ERK-1/2, AKT, LYN, SRC family kinases (SFKs) and NFκB (p50 RelA) were analysed in combination with SK1 and S1P receptors to discover novel prognostic interactions that drive cancer progression in ERα positive breast cancer patients. High …
-
Die Funktion des BAG1-Proteins ist abhängig von seiner subzellulären Verteilung
… des BAG1 für die Interaktion mit Hsp70 und Raf-1-Kinase wichtig ist. Damit ist die über BAG1 vermittelte Neuroprotektion und Zelldifferenzierung zum einen abhängig von der Interaktion von BAG1 mit Hsp70 bzw. Raf-1-Kinase und zum anderen abhängig von einer zytosolischen Lokalisation des BAG1. …
-
Die Rolle der Serin/Threonin Kinase Cot in Proliferation, Differenzierung und Apoptose
… der Maus untersucht. Expression von onkogenem c-Raf-1 oder v-Mos führt zu einer Differenzierung in PC12-Zellen. Cot induziert ebenfalls Neuritenbildung in diesen Zellen. Ähnlich wie v-raf hat onkogenes cot eine antiapoptotische Wirkung auf 32D-Zellen nach IL-3-Entzug. In neugeborenen NSF/N-Mäusen …
-
Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… by HDAC6 and has been implicated in stabilizing Raf-1 and ErbB2, I have found that suppression of HDAC6 impairs the stability of Raf-1 and the association between Hsp90 and ErbB2.</p><p>In conclusion, my work provides the first experimental evidence that of all the HDAC members, the cytoplasmic …
-
Mechanism-Based Strategies to Enhance The Actions of A
… stability of client oncoproteins, such as STAT3, Raf-1 and Akt, which play a role in the survival of malignant cells. The chaperone function of HSP90 is driven by the binding and hydrolysis of ATP. The geldanamycin analog, 17-AAG, binds to the ATP pocket of HSP90 leading to the degradation of …
-
Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
-
Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
-
Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
… activation of PKCδ and Src via parallel Raf-1→MEK1/2→ERK1/2 and MEK5→ERK5 signaling pathways. Using co-immunoprecipitation, TIRF-microscopy and FRAP, ET-1 stimulation of NRVM expressing a nonphosphorylatable, S910A-FAK mutant decreased the interaction of paxillin and vinculin within …
-
AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… kinase C (PKC) which in turn activated the c-Raf-1/MEK/ERK signaling cascade and triggered integrin α5 and δ-catenin expression. Together our data suggest that AKR1B10 promotes breast cancer metastasis through activation of PKC/ERK signaling pathway and upregulation of ii integrin α5 and …
-
Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
… keinen Einfluss, während dominant-negatives Raf-1 den IGF-1 Effekt auf HIF-1 alpha wiederum vollständig aufhob. Somit aktiviert IGF-1 die humane PAI-1- Genexpression durch die Aktivierung der PI(3)K und ERK1/2. Durch spezifische PI(3)K Inhibitoren war die Insulin-abhängige Steigerung der …
-
Generation and characterization of spred-2 knockout mice
… signaling pathway by interacting with Ras and Raf-1. Different studies have already demonstrated the inhibitory function of Spreds in cell culture systems, but the in vivo function of Spreds in the whole organism was still unclear. Therefore, Spred-2 knockout mice were generated using a gene …
-
The innate response to fungal infection
… for ERK1/2 activation. For most stimuli, Raf-1 activates MEK1/2 which activates ERK1/2, however in response to TLR signalling the kinase Tpl2 is required to activate MEK1/2. I show that the kinase responsible for ERK1/2 activation downstream of Dectin-1 is not Tpl2, but is an unidentified …
-
APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… and down-regulated the Hsp90 clientproteins Raf-1, survivin, Cdk4, Akt, and EGFR. Bulgarialactone B and other natural azaphilones showed antiproliferative activity in a panel of human tumor cell lines; their conversion into semisyntheticderivatives by reaction with primary amines increased …
-
Molecular mechanisms of KRas4b signaling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
-
B cell signalling in mechanisms of central and peripheral tolerance
… in full. For example, in B cells, the Ras/Raf-1/MEK cascade is considered to be a major pathway regulating ERK activation and consistent with this, this laboratory has previously shown that overexpression of Ras can rescue WEHI-231 B cells from BCR-mediated growth arrest. However, although …