Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Raf/MEK/ERK"”.
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Die Rolle mitogener und stressinduzierter MAPK-Signalwege in der Regulation von keratinozytären Wachstums- und Differenzierungsvorgängen
… Rolle in der Pathogenese vieler Hauterkrankungen. Die intrazellulären Signalmechanismen, die die Balance zwischen Keratinozytenwachstum und -differen-zierung steuern, sind bislang weitgehend unbekannt. In dieser Arbeit wurde die Bedeutung Mitogen-aktivierter Proteinkinase (MAPK-) …
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A Phase I Dose-Escalation Study of The Braf Inhibitor Vemurafenib In Combination With The Mtor Inhibitor Everolimus In Subjects With Advanced Cancer
<p>Vemurafenib has been approved in the United States for the treatment of relapsed or refractory BRAF mutation positive malignant melanoma and is being investigated in various other malignancies. The RAS/RAF/MEK/ERK (MAPK) pathway is critical to cell proliferation in many human cancers. The mTOR …
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DECIPHERING AND EXPLOITING ANEUPLOIDY IN CANCER
… damage. Notably, aneuploid cells had increased RAF/MEK/ERK pathway activity and were particularly sensitive to drugs targeting this pathway, especially those inhibiting CRAF. CRAF activity was also identified as a key factor in the resistance to DNA damage induction, with its inhibition …
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Scaffold-Mediated Organization of Signal Transduction Networks
The Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… that CRL4-DCAF1 facilitates KSR1 dependent RAF/Mitogen-activated protein kinase (MAPK)/ Extracellular signal regulated kinase (ERK) kinase (MEK)/ERK pathway activity. We showed MLN3651, a neddylation inhibitor that targets ubiquitin ligase activity, reduced proliferation and activated …
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Regulation of IL-6 signal transduction, contributions of the Signal Regulatory Protein (SIRP) and cyclic AMP
… part show an enhanced SHP2 phosphorylation and ERK1/2 activation in response to IL-6, suggesting that SIRP alpha affects IL-6-signalling through SHP2. Whereas SHP2 phosphorylation is enhanced in SIRP aplha-deficient cells STAT3 activation is delayed and STAT3-dependent gene induction is reduced. …
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Odorant receptors: regulation, signaling, and expression
… mediated by odorant receptors. Activation of the ERK cascade in neurons has been shown to participate in neuronal plasticity and gene expression. Data presented here extend this observation to olfactory sensory neurons of the channel catfish. A mixture of L-methionine and L-lysine, potent …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… its receptor functions drive phosphorylation of ERK, c-Cbl, and p85 PI3K. We found that crippling enzymatic activity with inhibitors or a point mutation (CD38 E226Q) did not affect ATRA induction, while a cytosolic truncation (CD38 [DELTA]11-20) that prevented CD38 membrane expression crippled …
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Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… led to induction of apoptosis and tumor xenograft regression suggesting that BCL2 is a potential therapeutic target in ASCL1-dependent NE-NSCLCs. Analysis of the upstream regulation of ASCL1 showed that it depends on a paradoxical activation of the RAS/RAF/MEK/ERK pathway. Small molecule …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… demonstrate that p53 activation inhibits N-Ras/Raf/MEK/ERK signaling and releases GSK3 activity to modulate MCL-1 phosphorylation and promote Mcl-1 degradation. Additionally, p53 activation also induces pro-apoptotic proteins such as PUMA and BAX to counteract MCL-1, thus overcoming Mcl-1 …
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MEK1 binds βarrestin1 directly, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
… It functions as an adaptor protein in the c-Raf/MEK/ERK cascade by interacting with c-Raf and ERK. In this study, I have shown that (1) β-arrestin1 can bind MEK1 directly, mediated at least in part by D26D29 of β-arrestin1 and R47K48R49 of MEK1. (2) Disruption of this association by …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… downstream effector proteins of KRAS, such as MEK inhibitors, have failed to produce significant clinical benefits. Previous studies by our group on the metastatic process revealed that malignant lung cancer cells undergo an epithelial-to-mesenchymal transition (EMT) that is regulated by a …
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PROTEINi screens identify ORP9 as a novel regulator of KRAS-driven signalling
… the excessive activation of the downstream RAF-MEK-ERK cascade, alongside additional pathways that promote cellular proliferation, survival and migration. KRAS traffics to the plasma membrane in order to be activated and bind to its effector proteins. Despite almost 40 years of research, …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… when TCR signalling was inhibited by the MEKinase inhibitor PD98059 or the Srckinase inhibitor PP1 myr PKB tg thymocytes again were more resistant to inhibition. Western blot analysis revealed myr PKB enhances activation of the kinases Lck, Raf and Erk after TCR/CD3 stimulation. Thus, myr …