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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Radiotracers"”.
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Evaluation of radiotracers for beta cell imaging
Contains fulltext : 169275.pdf (Publisher’s version ) (Open Access)
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Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… <sup>18</sup>F-labeled amino acid-based radiotracers have been reported as an alternative, which is based on the fact that tumor cells uptake and consume more amino acids to sustain their uncontrolled growth. Among those radiotracers, <sup>18</sup>F-labeled tyrosine and its derivatives …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… of positron emission tomography (PET) radiotracers that could be used for therapy planning. The goal of the first project was to design, synthesize, and evaluate PET radiotracers that could measure the enzymatic activation of Irinotecan (CPT-11), a potent chemotherapeutic used in the …
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Novel applications of fluorine-18 labelled radiotracers in cardiovascular disease
… authorities that govern the translation of radiotracers to the clinic. Whilst this probe holds promise for the non-invasive identification of thrombus formation in cardiovascular disease, it is not ready for human translation in its current form.
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Radiotracers and NMR as in situ probes at the electrochemical interface
The design and construction of a radiotracer instrument which allows the quantitative measurement of a radiolabeled adsorbate on atomically smooth electrodes for the first time is described. Using this instrument, the surface mobilities of three organic molecules (pyridine, formic acid, and acetic …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… HDAC class IIa, SIRT1 and SIRT2-selective radiotracers have been developed and validated through in vitro and in vivo characterization. Two of these tracers, 18F-TFAHA for HDAC class IIa and and 2-[18F]PhAHA for SIRT1, have also been validated in a disease model demonstrating their utility …
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Synthesis and Characterization of Novel Nanoparticles for Use as Photocatalytic Probes and Radiotracers
… doped magnetite nanoparticles for application as radiotracers for in vivo fate studies. The labeled particles will be useful for determination of pharmacological behavior in biological systems. Indium doped magnetite particles with varying size and surface chemistry were synthesized with wet …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
Efforts toward understanding the endocannabinoid system, which is comprised of cannabinoid receptors and endogenous ligands, have rapidly expanded in recent years. The endocannabinoid system can modulate the activity of other neurotransmitters through the type 1 cannabinoid receptor (CB1R) which is …
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Einflussgrößen der Nephrotoxizität eines Radiotracers am Beispiel der Radioimmuntherapie mit 188Re-anti-CD66
Die Nephrotoxizität ist die wichtigste Nebenwirkung bei Applikation von Radioimmunkonjugaten zur Konditionierung des Knochenmarks bei der Leukämiebehandlung. Die Auswirkungen der Unsicherheiten bei der Dosisbestimmung der Niere, insbesondere durch individuelle Nierenmasse und regionale …
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Development of PET Radiotracers for Imaging Neurodegeneration: Targeting alpha-Synuclein Fibrils and TSPO
… This is achieved through application of radiotracers – compounds labelled with positron emitting radionuclides. Neurodegeneration is the progressive loss of neurons resulting in impairment of brain function leading to cognitive decline and can affect movement. The underlying pathology of …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… that applies highly selective and sensitive radiotracers to biological markers. Imaging with PET radiotracers is a powerful means for the assessment and early detection of various diseases such as neurological diseases, cardiovascular diseases and cancer. Neuroinflammation is an inflammatory …
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Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals
A series of 1,4-diaminobutane poly(propylene amine) (DAB-PPI) dendrimer-based ligands were prepared with the aim of developing ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom …
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Development of a System for Real-Time Measurements of Metabolite Transport in Plants Using Short-Lived Positron-Emitting Radiotracers
… in plants using short-lived positron-emitting radiotracers. This thesis project includes the design, construction, and demonstration of the capabilities of this system for performing real-time measurements of metabolite transport in plants.</p><p>The short-lived radiotracer system described in …
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Micro- and millifluidic platforms for imaging agent synthesis
… due to improvements in the regulation of PET radiotracers and the development of multimodal imaging set-ups that combine the sensitivity of PET with X-ray computed tomography (CT) or magnetic resonance imaging (MRI) that provide anatomical details. To date the most widely used PET radiotracer …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… PET are non-invasive imaging techniques in which radiotracers are used to study biochemical and physiological functions in the living brain. In vivo brain mapping with PET or SPECT can be of great importance in drug development as well as in the effective diagnosis, treatment and management of …
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Gel electrophoresis for elemental speciation purposes
… trace elements that do not rely on the use of radiotracers were applied, making this combination relevant for materials of human origin, where the use of radioactive material is restricted for reasons of safety.
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I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18
… Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with F-18 that enable the preparation of a wide variety of radiotracers, rapidly, efficiently and conveniently are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET …
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Anions in hydrophobic environments: liquid-liquid extraction of sulfate and chloride, and membrane transport of chloride
… the partitioning analysis of sulfate using radiotracers. Chapter 3 explores the chloride extraction behavior of several pyrrole-based molecules using radiotracer analysis. Chapter 4 details the extensive studies of chloride transport across lipid bilayers using liposome model membranes.
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled …
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