Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Radiosensitizers"”.
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The synthesis and characterization of water soluble platinum (II) pophyrins and their potential as radiosensitizers
… have been developed. Such compounds are termed radiosensitizers. The synthesis of novel platinum(II) porphyrins was undertaken in an attempt to create effective new radiosensitizers. Platinum complexes of the methylated pyridinium porphyrins(shown in the figure below) were synthesized, and …
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Reoxygenation of hypoxic coronary smooth muscle cells amplifies growth-retarding effects of ionizing irradiation
… On the basis of these findings, oxygenating radiosensitizers should be analysed with regard to suitablility for coronary brachytherapy to prevent restenosis.
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
… Our results indicate that VEGF-A and VEGF-C are radiosensitizers while AZD2171 did not modulate the radioresponse. In vivo, normal lymphatics were studied with the experimental group receiving a single fraction of 8 Gy and the control group receiving no radiation. We observed no difference in the …
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… pathways, suggesting their potential as radiosensitizers. To identify miRNAs likely to be involved in influencing PCa radiation response, we first performed miRNA profiling analysis of PCa cell lines exposed to photon irradiation. Based on their modulation upon radiation exposure, and …
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Development of Gold-Magnetite Hybrid Nanoparticles for Advanced Radiotherapy
… of nanoparticles as MRI-contrast agents and radiosensitizers. A novel method for the synthesis of hydrophilic and superparamagnetic Tween20-stabilized dumbbell-like gold-magnetite hybrid nanoparticles was set up. Morphology and chemical composition of nanoparticles were assessed by …
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Nanoparticles for Simultaneous Assessment of Ros and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes
… density and atomic number NPs act both as a radiosensitizers and radioenhancers with high radiation dose enhancement (DE) properties that enhances the local dose through the release of more secondary electrons, radiochemical yields through enhanced ROS generation in within the tumour volumes. …
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Interaction of the potential DNA-radiosensitizer 8-bromoadenine with free and plasmonically generated electrons
… of the interaction of less toxic potential radiosensitizers with secondary reactive species like LEEs. Beyond that LEEs can be generated by laser illuminated nanoparticles that are applied in photothermal therapy (PTT) of cancer, which is an attempt to treat cancer by an increase of …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
Brain cancer is the second leading cause of cancer-related deaths in children in the United States, with medulloblastoma leading all pediatric cases. With intensive treatments, including surgery, radiation, and/or chemotherapy, the average 5-year survival rate is approximately 60-80 percent. …
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Porphyrin chemistry pertaining to the design of anticancer agents
… synthesize and test for potential porphyrin radiosensitizers with improved tumor selectivity. The rationale was that the radio sensitization abilities of the porphyrins might be improved by introduction of certain functional groups (including nitro groups and metal ions), while retaining or …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
<p>Retrospective data analysis suggests that inflammatory breast cancer (IBC) patients who take statins have better locoregional control after radiotherapy than those who do not [23]. Our lab has previously demonstrated that simvastatin radiosensitizes IBC cells in vitro [23], and brain metastases …